PMID- 18398417
OWN - NLM
STAT- MEDLINE
DCOM- 20080730
LR  - 20211020
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 28
IP  - 7
DP  - 2008 Jul
TI  - Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate 
      prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK 
      activation despite drastic ATP loss.
PG  - 1307-19
LID - 10.1038/jcbfm.2008.20 [doi]
AB  - Oxygen-glucose deprivation (OGD) initiates a cascade of intracellular responses 
      that culminates in cell death in sensitive species. Neurons from Arctic ground 
      squirrels (AGS), a hibernating species, tolerate OGD in vitro and global ischemia 
      in vivo independent of temperature or torpor. Regulation of energy stores and 
      activation of mitogen-activated protein kinase (MAPK) signaling pathways can 
      regulate neuronal survival. We used acute hippocampal slices to investigate the 
      role of ATP stores and extracellular signal-regulated kinase (ERK)1/2 and Jun 
      NH(2)-terminal kinase (JNK) MAPKs in promoting survival. Acute hippocampal slices 
      from AGS tolerated 30 mins of OGD and showed a small but significant increase in 
      cell death with 2 h OGD at 37 degrees C. This tolerance is independent of 
      hibernation state or season. Neurons from AGS survive OGD despite rapid ATP 
      depletion by 3 mins in interbout euthermic AGS and 10 mins in hibernating AGS. 
      Oxygen-glucose deprivation does not induce JNK activation in AGS and baseline 
      ERK1/2 and JNK activation is maintained even after drastic depletion of ATP. 
      Surprisingly, inhibition of ERK1/2 or JNK during OGD had no effect on survival, 
      whereas inhibition of JNK increased cell death during normoxia. Thus, protective 
      mechanisms promoting tolerance to OGD by AGS are downstream from ATP loss and are 
      independent of hibernation state or season. Journal of Cerebral Blood Flow & 
      Metabolism (2008) 28, 1307-1319; doi:10.1038/jcbfm.2008.20; published online 9 
      April 2008.
FAU - Christian, Sherri L
AU  - Christian SL
AD  - Alaskan Basic Neuroscience Program, Institute of Arctic Biology, University of 
      Alaska Fairbanks, Fairbanks, Alaska 99775-7000, USA.
FAU - Ross, Austin P
AU  - Ross AP
FAU - Zhao, Huiwen W
AU  - Zhao HW
FAU - Kristenson, Heidi J
AU  - Kristenson HJ
FAU - Zhan, Xinhua
AU  - Zhan X
FAU - Rasley, Brian T
AU  - Rasley BT
FAU - Bickler, Philip E
AU  - Bickler PE
FAU - Drew, Kelly L
AU  - Drew KL
LA  - eng
GR  - U54 NS041069/NS/NINDS NIH HHS/United States
GR  - U54 NS041069-050002/NS/NINDS NIH HHS/United States
GR  - NS41069/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080409
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adaptation, Physiological
MH  - Adenosine Triphosphate/*physiology
MH  - Animals
MH  - Cell Survival
MH  - Glucose/*metabolism
MH  - Hibernation
MH  - Hippocampus/*cytology
MH  - JNK Mitogen-Activated Protein Kinases/*physiology
MH  - Mitogen-Activated Protein Kinase 3/*physiology
MH  - Neurons/cytology/enzymology/*metabolism
MH  - Oxygen/*metabolism
MH  - Sciuridae/physiology
PMC - PMC2792705
MID - NIHMS158437
EDAT- 2008/04/10 09:00
MHDA- 2008/07/31 09:00
PMCR- 2009/12/14
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/07/31 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
PHST- 2009/12/14 00:00 [pmc-release]
AID - jcbfm200820 [pii]
AID - 10.1038/jcbfm.2008.20 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2008 Jul;28(7):1307-19. doi: 10.1038/jcbfm.2008.20. 
      Epub 2008 Apr 9.