PMID- 18398813
OWN - NLM
STAT- MEDLINE
DCOM- 20080606
LR  - 20150330
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 5
IP  - 1
DP  - 2008 Mar
TI  - Drinking modulates monocyte migration in healthy subjects: a randomised 
      intervention study of water, ethanol, red wine and beer with or without alcohol.
PG  - 48-53
LID - 10.3132/dvdr.2008.009 [doi]
AB  - Moderate alcohol consumption is associated with reduced cardiovascular mortality 
      compared to non-consumption of alcohol and heavy drinking. Experimental data 
      suggest a direct effect of alcohol on atherosclerotic lesion development. We 
      assessed the effect of consumption of moderate amounts of alcoholic and 
      non-alcoholic beverages on monocyte migration, a crucial step in atherogenesis. 
      Forty-nine healthy men and women (aged 22-56 years) were enrolled in this 
      randomised controlled trial. After wash-out, participants were assigned to either 
      ethanol (concentration 12.5%), beer (5.6%) or red wine (12.5%) equivalent to 30 
      grams of ethanol per day (g/d) for men and 20 g/d for women, or to the same 
      amount of de-alcoholised beer or red wine, or to water. Monocyte migration was 
      evaluated ex vivo using a modified Boyden chamber. Intake of ethanol or 
      de-alcoholised red wine significantly reduced monocyte chemoattractant protein-1 
      (MCP-1)-induced monocyte migration by 58% (p<0.05; n=6) and 36% (p<0.05; n=7) and 
      FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced migration by 41% (p<0.05) 
      and 36% (p<0.05), respectively. MCP-1 receptor expression was not affected by 
      these interventions, as shown by flow cytometry. Short-term intervention with 
      moderate amounts of ethanol and de-alcoholised red wine inhibits monocyte 
      migration ex vivo. This might represent one mechanism by which alcoholic 
      beverages lower cardiovascular risk.
FAU - Imhof, Armin
AU  - Imhof A
AD  - Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Medical 
      Centre, Robert-Koch-Strasse 8, D-89081 Ulm, Germany. armin.imhof@uni-ulm.de
FAU - Blagieva, Roza
AU  - Blagieva R
FAU - Marx, Nikolaus
AU  - Marx N
FAU - Koenig, Wolfgang
AU  - Koenig W
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 059QF0KO0R (Water)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/*immunology
MH  - Atherosclerosis/*immunology
MH  - Beer
MH  - Chemokine CCL2/metabolism
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - E-Selectin/metabolism
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*physiology
MH  - Water/pharmacology
MH  - Wine
EDAT- 2008/04/10 09:00
MHDA- 2008/06/07 09:00
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/06/07 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - 2975 [pii]
AID - 10.3132/dvdr.2008.009 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2008 Mar;5(1):48-53. doi: 10.3132/dvdr.2008.009.