PMID- 18398848
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20131121
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 18
IP  - 7
DP  - 2008
TI  - Combined neonatal stress and young-adult glucocorticoid stimulation in rats 
      reduce BDNF expression in hippocampus: effects on learning and memory.
PG  - 655-67
LID - 10.1002/hipo.20425 [doi]
AB  - Epidemiological studies suggest that multiple developmental disruptions are 
      involved in the etiology of psychiatric illnesses including schizophrenia. In 
      addition, altered expression of brain-derived neurotrophic factor (BDNF) has been 
      implicated in these illnesses. In the present study, we examined the combined 
      long-term effect of an early stress, in the form of maternal deprivation, and a 
      later stress, simulated by chronic young-adult treatment with the stress hormone, 
      corticosterone, on BDNF expression in the hippocampus of rats. To assess whether 
      there were behavioral effects, which may correlate with the BDNF changes, 
      learning and memory was tested in the Y-maze test for short term spatial memory, 
      the Morris water maze for long-term spatial memory, and the T-maze test for 
      working memory. Four groups of rats received either no stress, maternal 
      deprivation, corticosterone treatment, or both. Dorsal hippocampus sections 
      obtained from parallel groups were used for BDNF mRNA in situ hybridization. Rats 
      which had undergone both maternal deprivation and corticosterone treatment 
      displayed a unique and significant 25-35% reduction of BDNF expression in the 
      dentate gyrus (DG), and similar trends in the CA1 and CA3 regions of the 
      hippocampus. These "two-hit" animals exhibited a learning delay in the Morris 
      water maze test, a marked deficit in the Y-maze, but little change in the T-maze 
      test. However, some aspects of cognition were also altered in rats with either 
      maternal deprivation or corticosterone treatment. This study demonstrates a 
      persistent effect of two developmental disruptions on BDNF expression in the 
      hippocampus, with parallel, but not completely correlative changes in learning 
      and memory.
FAU - Choy, Kwok Ho Christopher
AU  - Choy KH
AD  - Behavioural Neuroscience Laboratory, Mental Health Research Institute of 
      Victoria, Melbourne, Australia.
FAU - de Visser, Yvonne
AU  - de Visser Y
FAU - Nichols, Nancy R
AU  - Nichols NR
FAU - van den Buuse, Maarten
AU  - van den Buuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Animals, Outbred Strains
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Corticosterone/*pharmacology
MH  - Gene Expression/drug effects/physiology
MH  - Hippocampus/*physiology
MH  - In Situ Hybridization
MH  - Male
MH  - Maternal Deprivation
MH  - Maze Learning/drug effects/physiology
MH  - Memory, Short-Term/drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects/physiology
MH  - Stress, Psychological/metabolism/*physiopathology
EDAT- 2008/04/10 09:00
MHDA- 2008/08/21 09:00
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - 10.1002/hipo.20425 [doi]
PST - ppublish
SO  - Hippocampus. 2008;18(7):655-67. doi: 10.1002/hipo.20425.