PMID- 18399156
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20111117
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 28
IP  - 10
DP  - 2007 Oct
TI  - [Study on the relationship between chronic glomerulonephritis and human leukocyte 
      antigen in Shandong province].
PG  - 1030-5
AB  - OBJECTIVE: The purpose of this study was to observe the association between 
      chronic glomerulonephritis (CGN) and human leukocyte antigen (HLA) on DNA level 
      in order to identify susceptible and protective genes and to further explain the 
      possible pathogenesis of CGN. METHODS: 1073 renal transplantation patients with 
      Han ethnicity were included in this study. All patients were recruited from three 
      provincial Hospitals during the past ten years. The control group contained 7418 
      healthy Han volunteer donors from Shandong Hematopoietic Stem Cell Data Bank of 
      China. We collected data about the polymorphism of HLA-I , II and DRB1. Gene 
      frequency (GF), relative risk (RR) and correlation test were analyzed using 
      statistical software. Some patients carrying the susceptible genes were followed 
      up for 1,3 and 5 years, and compared their survival rate respectively. RESULTS: 
      The frequency of HLA-A23, A25,B15, B40, B53 and DRB1 * 18 alleles increased 
      significantly in CGN patients than in controls, showing that they might be the 
      suspicious susceptibility genes of CGN. After the follow-up periods, the 
      prognosis of patients with the susceptible genes was worse than the controls. The 
      frequency of haplotypes of A23-B44-DRB1 * 18, A25-B15-DRB1 * 07, A3-B70-DRB1 * 
      11, A68-B13-DRB1 * 04, A11-B10-DRB1 * 12 increased significantly in CGN patients 
      than in controls. There were 8 lower frequencies alleles (including A20, A22, 
      A35, A36, A38, B21, B73 and B78) in CGN patients that were not found in the 
      control group. The frequencies of the HLA-A32, A33, B50, B58, B60, B71, DRB1 * 16 
      alleles decreased significantly in CGN patients than in controls, showing that 
      they might be the protective genes of CGN. CONCLUSION: Our data showed that there 
      might be corresponding susceptibility and protective genes of CGN in Han 
      population, in Shandong. There was significant association between the five 
      common haplotype and CGN in Shandong population. However, the prognosis of the 
      patients with the susceptibility genes was worse than the controls.
FAU - Zhao, Jing-jie
AU  - Zhao JJ
AD  - Laboratory of Clinical Molecular Biology, Second Hospital of Shandong University, 
      Jinan, China.
FAU - Liu, Jun-li
AU  - Liu JL
FAU - Zhang, Cai
AU  - Zhang C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Glomerulonephritis/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Young Adult
EDAT- 2008/04/11 09:00
MHDA- 2010/05/14 06:00
CRDT- 2008/04/11 09:00
PHST- 2008/04/11 09:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
PHST- 2008/04/11 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Oct;28(10):1030-5.