PMID- 18400298
OWN - NLM
STAT- MEDLINE
DCOM- 20090102
LR  - 20131121
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 34
IP  - 7
DP  - 2008 Oct
TI  - Bioaccumulation of chlorinated pesticides and PCBs in the tropical freshwater 
      fish Hoplias malabaricus: histopathological, physiological, and immunological 
      findings.
PG  - 939-49
LID - 10.1016/j.envint.2008.02.004 [doi]
AB  - For assessing the impact of chlorinated compounds, such as organochlorine 
      pesticides, polychlorinated biphenyls, chlorotriazines (atrazine, simazine), and 
      chlorinated phenylureas (diuron), on the Ponta Grossa lake South of Brazil, ten 
      freshwater trahira fish (Hoplias malabaricus) were collected in October 2005. The 
      contamination status was evaluated by the energy budget and various 
      histopathological markers. The results showed detectable amounts of persistent 
      organic pollutants (POPs) in the liver and muscle; the bioaccumulation was higher 
      in the liver than in the muscle. The presence of some banned pesticides, such as 
      hexachlorobenzene and dichlorodiphenyltrichloroethane, in the liver suggests an 
      acute exposure to these compounds. Some physiological disturbances and 
      morphological damages found in the liver of H. malabaricus were associated with 
      chlorinated-compound bioaccumulation. The most important alterations in the liver 
      were lesions such as fibrosis, large necrosis area, leukocyte infiltration, and 
      the absence of melanomacrophages (MM). Individuals containing higher 
      concentrations of pesticides, such as aldrin, alachlor, and dichloroaniline (a 
      metabolite of diuron), showed the nonoccurrence of MM in the liver. These data 
      suggest an immunosuppression in the individuals from Ponta Grossa Lake after 
      exposure to POPs. According to the present data, the POPs found in the studied 
      site are bioavailable, induce severe damages in target organs such as the liver, 
      and can disturb the immune system of the trahira. This is the first study of POPs 
      in the Parana state, and one among the few studies in the south of Brazil. The 
      present data suggest and motivate further chemical and biomonitoring studies in 
      freshwater ecosystems in the south of Brazil.
FAU - Miranda, A L
AU  - Miranda AL
AD  - Departamento de Biologia Celular, Universidade Federal do Parana, Caixa Postal 
      19031, CEP: 81, 531-990, Curitiba, PR, Brazil.
FAU - Roche, H
AU  - Roche H
FAU - Randi, M A F
AU  - Randi MA
FAU - Menezes, M L
AU  - Menezes ML
FAU - Ribeiro, C A Oliveira
AU  - Ribeiro CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080408
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Fishes/immunology/*metabolism/physiology
MH  - Fresh Water
MH  - Hydrocarbons, Chlorinated/*metabolism
MH  - Liver/pathology
MH  - Pesticides/*metabolism
MH  - Polychlorinated Biphenyls/*metabolism
MH  - Water Pollutants, Chemical/*metabolism
EDAT- 2008/04/11 09:00
MHDA- 2009/01/03 09:00
CRDT- 2008/04/11 09:00
PHST- 2007/06/22 00:00 [received]
PHST- 2007/11/21 00:00 [revised]
PHST- 2008/02/15 00:00 [accepted]
PHST- 2008/04/11 09:00 [pubmed]
PHST- 2009/01/03 09:00 [medline]
PHST- 2008/04/11 09:00 [entrez]
AID - S0160-4120(08)00025-1 [pii]
AID - 10.1016/j.envint.2008.02.004 [doi]
PST - ppublish
SO  - Environ Int. 2008 Oct;34(7):939-49. doi: 10.1016/j.envint.2008.02.004. Epub 2008 
      Apr 8.