PMID- 18402781
OWN - NLM
STAT- MEDLINE
DCOM- 20080806
LR  - 20220311
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 41
IP  - 10-11
DP  - 2008 Jul
TI  - Serum brain-derived neurotrophic factor in patients with type 2 diabetes 
      mellitus: Relationship to glucose metabolism and biomarkers of insulin 
      resistance.
PG  - 812-7
LID - 10.1016/j.clinbiochem.2008.03.003 [doi]
AB  - OBJECTIVES: The aims of this study were to measure serum levels of brain-derived 
      neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and 
      to investigate the association of these BDNF levels with biomarkers of glucose 
      metabolism and insulin resistance. DESIGN AND METHODS: We studied 112 patients 
      with T2DM and 80 age- and gender-matched control subjects. RESULTS: Serum BDNF 
      levels were significantly lower in patients with T2DM compared to control 
      subjects (15.5+/-5.2 ng/mL vs. 20.0+/-7.3 ng/mL, P<0.01). In patients with T2DM, 
      BDNF levels were significantly higher in females than in males (P<0.01). In the 
      female patients, BDNF was positively related to immunoreactive insulin (IRI) 
      (rho=0.458, P<0.05) and HOMA-R (rho=0.444, P<0.05). Stepwise multiple regression 
      analysis showed a significant relationship between BDNF and IRI (F=5.294, P<0.05) 
      in female patients with diabetes. CONCLUSIONS: These findings suggest that BDNF 
      may contribute to glucose metabolism.
FAU - Fujinami, Aya
AU  - Fujinami A
AD  - Department of Medical Biochemistry, Kobe Pharmaceutical University, 4-19-1 
      Motoyama-kita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
FAU - Ohta, Kiyoe
AU  - Ohta K
FAU - Obayashi, Hiroshi
AU  - Obayashi H
FAU - Fukui, Michiaki
AU  - Fukui M
FAU - Hasegawa, Goji
AU  - Hasegawa G
FAU - Nakamura, Naoto
AU  - Nakamura N
FAU - Kozai, Hana
AU  - Kozai H
FAU - Imai, Saeko
AU  - Imai S
FAU - Ohta, Mitsuhiro
AU  - Ohta M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080319
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adiponectin/blood
MH  - Aged
MH  - Albuminuria
MH  - Blood Glucose/*metabolism
MH  - Blood Pressure
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Leptin/blood
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Reference Values
EDAT- 2008/04/12 09:00
MHDA- 2008/08/07 09:00
CRDT- 2008/04/12 09:00
PHST- 2008/01/07 00:00 [received]
PHST- 2008/03/02 00:00 [revised]
PHST- 2008/03/04 00:00 [accepted]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2008/08/07 09:00 [medline]
PHST- 2008/04/12 09:00 [entrez]
AID - S0009-9120(08)00123-9 [pii]
AID - 10.1016/j.clinbiochem.2008.03.003 [doi]
PST - ppublish
SO  - Clin Biochem. 2008 Jul;41(10-11):812-7. doi: 10.1016/j.clinbiochem.2008.03.003. 
      Epub 2008 Mar 19.