PMID- 18402983
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20220321
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 82
IP  - 17-18
DP  - 2008 Apr 23
TI  - Chronic mild stress impairs cognition in mice: from brain homeostasis to 
      behavior.
PG  - 934-42
LID - 10.1016/j.lfs.2008.02.010 [doi]
AB  - Exposure to chronic stress in rodents and psychosocial stress in humans has been 
      shown to alter cognitive functions and has been linked to the pathophysiology of 
      mood disorders. The purpose of the present study was to investigate effects and 
      possible mechanisms of a chronic mild stress (CMS) procedure on cognitive 
      behaviors in Swiss albino mice using the object recognition test (ORT) and object 
      location test (OLT). Results showed that CMS exposure impaired cognitive 
      performance and produced amnesia of acquired information in both ORT and OLT. 
      Furthermore, the cognitive impairment was coexistent with increased plasma levels 
      of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis 
      factor-alpha (TNF-alpha), as well as with enhanced plasma levels of 
      corticosterone (CORT), corticotrophin-releasing hormone (CRH) and 
      adrenocorticotrophic hormone (ACTH). In addition, severe neuronal cell damage was 
      found, as bromodeoxyuridine (BrdU) positive cells and the expression of brain 
      derived neurotrophic factor (BDNF) in dentate gyrus (DG) of hippocampus were 
      decreased after 5 weeks CMS procedure. Taken together, these findings indicated 
      that CMS exposure-induced impairment of cognitive behaviors might be attributed 
      to the stress-related alterations in brain homeostasis that were reflected in 
      changes in the neuroimmune and neuroendocrine systems as well as in neurogenesis.
FAU - Li, Song
AU  - Li S
AD  - Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University 
      of Technology, Dalian, 116024, China. lisong_spu2005@yahoo.com
FAU - Wang, Che
AU  - Wang C
FAU - Wang, Wei
AU  - Wang W
FAU - Dong, Huiping
AU  - Dong H
FAU - Hou, Peng
AU  - Hou P
FAU - Tang, Yiyuan
AU  - Tang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080304
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Antimetabolites)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Antimetabolites/pharmacology
MH  - Behavior, Animal/*physiology
MH  - Brain/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Bromodeoxyuridine/pharmacology
MH  - Chronic Disease
MH  - Cognition Disorders/*etiology/psychology
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/blood
MH  - Eating/physiology
MH  - Hippocampus/drug effects/metabolism
MH  - Homeostasis/*physiology
MH  - Immunohistochemistry
MH  - Interleukin-1beta/biosynthesis
MH  - Interleukin-6/biosynthesis
MH  - Male
MH  - Mice
MH  - Nerve Growth Factors/biosynthesis
MH  - Neuroimmunomodulation/physiology
MH  - Recognition, Psychology/physiology
MH  - Stress, Psychological/*physiopathology/*psychology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2008/04/12 09:00
MHDA- 2008/06/18 09:00
CRDT- 2008/04/12 09:00
PHST- 2007/08/14 00:00 [received]
PHST- 2008/01/27 00:00 [revised]
PHST- 2008/02/19 00:00 [accepted]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/04/12 09:00 [entrez]
AID - S0024-3205(08)00091-X [pii]
AID - 10.1016/j.lfs.2008.02.010 [doi]
PST - ppublish
SO  - Life Sci. 2008 Apr 23;82(17-18):934-42. doi: 10.1016/j.lfs.2008.02.010. Epub 2008 
      Mar 4.