PMID- 18403002
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20240312
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 90
IP  - 2
DP  - 2008 Aug
TI  - Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is 
      correlated with dialysate levels of serotonin and dopamine in rat brain.
PG  - 208-17
LID - 10.1016/j.pbb.2008.02.018 [doi]
AB  - (+/-)-3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy) is an illicit drug 
      that evokes transporter-mediated release of monoamines, including serotonin 
      (5-HT) and dopamine (DA). Here we monitored the effects of MDMA on neurochemistry 
      and motor activity in rats, as a means to evaluate relationships between 5-HT, 
      DA, and behavior. Male rats undergoing in vivo microdialysis were housed in 
      chambers equipped with photobeams for measurement of ambulation (i.e., forward 
      locomotion) and stereotypy (i.e., head weaving and forepaw treading). 
      Microdialysis probes were placed into the n. accumbens, striatum or prefrontal 
      cortex in separate groups of rats. Dialysate samples were assayed for 5-HT and DA 
      by microbore HPLC-ECD. Rats received two i.v. injections of MDMA, 1 mg/kg 
      followed by 3 mg/kg 60 min later; neurochemical and locomotor parameters were 
      measured concurrently. MDMA produced dose-related elevations in extracellular 
      5-HT and DA in all regions, with the magnitude of 5-HT release always exceeding 
      that of DA release. MDMA-induced ambulation was positively correlated with 
      dialysate DA levels in all regions (P<0.05-0.0001) and with dialysate 5-HT in 
      striatum and cortex (P<0.001-0.0001). Stereotypy was strongly correlated with 
      dialysate 5-HT in all areas (P<0.001-0.0001) and with dialysate DA in accumbens 
      and striatum (P<0.001-0.0001). These data support previous work and suggest the 
      complex spectrum of behaviors produced by MDMA involves 5-HT and DA in a region- 
      and modality-specific manner.
FAU - Baumann, Michael H
AU  - Baumann MH
AD  - Clinical Psychopharmacology Section, Intramural Research Program, National 
      Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, 
      United States. mbaumann@mail.nih.gov
FAU - Clark, Robert D
AU  - Clark RD
FAU - Rothman, Richard B
AU  - Rothman RB
LA  - eng
GR  - Z99 DA999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20080304
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/drug effects/metabolism
MH  - Dopamine/*metabolism/physiology
MH  - Male
MH  - *Microdialysis
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT2C/physiology
MH  - Serotonin/*metabolism/physiology
PMC - PMC2491560
MID - NIHMS55860
EDAT- 2008/04/12 09:00
MHDA- 2008/08/13 09:00
PMCR- 2009/08/01
CRDT- 2008/04/12 09:00
PHST- 2007/07/24 00:00 [received]
PHST- 2007/12/27 00:00 [revised]
PHST- 2008/02/19 00:00 [accepted]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/04/12 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0091-3057(08)00065-8 [pii]
AID - 10.1016/j.pbb.2008.02.018 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2008 Aug;90(2):208-17. doi: 10.1016/j.pbb.2008.02.018. 
      Epub 2008 Mar 4.