PMID- 18403137
OWN - NLM
STAT- MEDLINE
DCOM- 20090205
LR  - 20080815
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 131
IP  - 1-2
DP  - 2008 Sep 18
TI  - Isolation and genetic characterization of avian origin H9N2 influenza viruses 
      from pigs in China.
PG  - 82-92
LID - 10.1016/j.vetmic.2008.02.024 [doi]
AB  - As pigs are susceptible to infection with both avian and human influenza A 
      viruses, they have been proposed to be an intermediate host for the adaptation of 
      avian influenza viruses to humans. In April 2006, a disease caused by highly 
      pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) occurred 
      in several pig farms and subsequently overwhelmed almost half of China with more 
      than 2,000,000 cases of pig infection. Here we report a case in which four swine 
      H9N2 influenza viruses were isolated from pigs infected by highly pathogenic 
      PRRSVs in Guangxi province in China. All the eight gene segments of the four 
      swine H9N2 viruses are highly homologous to A/Pigeon/Nanchang/2-0461/00 (H9N2) or 
      A/Wild Duck/Nanchang/2-0480/00 (H9N2). Phylogenetic analyses of eight genes show 
      that the swine H9N2 influenza viruses are of avian origin and may be the 
      descendants of A/Duck/Hong Kong/Y280/97-like viruses. Molecular analysis of the 
      HA gene indicates that our H9N2 isolates might have high-affinity binding to the 
      alpha2,6-NeuAcGal receptor found in human cells. In conclusion, our finding 
      provides further evidence about the interspecies transmission of avian influenza 
      viruses to pigs and emphasizes the importance of reinforcing swine influenza 
      virus (SIV) surveillance, especially after the emergence of highly pathogenic 
      PRRSVs in pigs in China.
FAU - Yu, Hai
AU  - Yu H
AD  - National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
FAU - Hua, Rong-Hong
AU  - Hua RH
FAU - Wei, Tian-Chao
AU  - Wei TC
FAU - Zhou, Yan-Jun
AU  - Zhou YJ
FAU - Tian, Zhi-Jun
AU  - Tian ZJ
FAU - Li, Guo-Xin
AU  - Li GX
FAU - Liu, Tian-Qiang
AU  - Liu TQ
FAU - Tong, Guang-Zhi
AU  - Tong GZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080306
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Adaptation, Physiological
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - China/epidemiology
MH  - Disease Outbreaks/veterinary
MH  - Humans
MH  - Influenza A Virus, H9N2 Subtype/*classification/*genetics/isolation & 
      purification/physiology
MH  - Molecular Sequence Data
MH  - Orthomyxoviridae Infections/epidemiology/transmission/*veterinary/virology
MH  - *Phylogeny
MH  - Sequence Homology, Nucleic Acid
MH  - Species Specificity
MH  - Swine
MH  - Swine Diseases/epidemiology/transmission/*virology
MH  - *Zoonoses
EDAT- 2008/04/12 09:00
MHDA- 2009/02/06 09:00
CRDT- 2008/04/12 09:00
PHST- 2007/11/01 00:00 [received]
PHST- 2008/02/23 00:00 [revised]
PHST- 2008/02/28 00:00 [accepted]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2009/02/06 09:00 [medline]
PHST- 2008/04/12 09:00 [entrez]
AID - S0378-1135(08)00099-0 [pii]
AID - 10.1016/j.vetmic.2008.02.024 [doi]
PST - ppublish
SO  - Vet Microbiol. 2008 Sep 18;131(1-2):82-92. doi: 10.1016/j.vetmic.2008.02.024. 
      Epub 2008 Mar 6.