PMID- 18403396
OWN - NLM
STAT- MEDLINE
DCOM- 20090309
LR  - 20220408
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 19
IP  - 1
DP  - 2009 Jan
TI  - Resting-state functional connectivity reflects structural connectivity in the 
      default mode network.
PG  - 72-8
LID - 10.1093/cercor/bhn059 [doi]
AB  - Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies 
      constitute a growing proportion of functional brain imaging publications. This 
      approach detects temporal correlations in spontaneous blood oxygen 
      level-dependent (BOLD) signal oscillations while subjects rest quietly in the 
      scanner. Although distinct resting-state networks related to vision, language, 
      executive processing, and other sensory and cognitive domains have been 
      identified, considerable skepticism remains as to whether resting-state 
      functional connectivity maps reflect neural connectivity or simply track BOLD 
      signal correlations driven by nonneural artifact. Here we combine diffusion 
      tensor imaging (DTI) tractography with resting-state fcMRI to test the hypothesis 
      that resting-state functional connectivity reflects structural connectivity. 
      These 2 modalities were used to investigate connectivity within the default mode 
      network, a set of brain regions--including medial prefrontal cortex (MPFC), 
      medial temporal lobes (MTLs), and posterior cingulate cortex (PCC)/retropslenial 
      cortex (RSC)--implicated in episodic memory processing. Using seed regions from 
      the functional connectivity maps, the DTI analysis revealed robust structural 
      connections between the MTLs and the retrosplenial cortex whereas tracts from the 
      MPFC contacted the PCC (just rostral to the RSC). The results demonstrate that 
      resting-state functional connectivity reflects structural connectivity and that 
      combining modalities can enrich our understanding of these canonical brain 
      networks.
FAU - Greicius, Michael D
AU  - Greicius MD
AD  - Department of Neurology, Stanford University School of Medicine, Stanford, CA 
      94304, USA. greicius@stanford.edu
FAU - Supekar, Kaustubh
AU  - Supekar K
FAU - Menon, Vinod
AU  - Menon V
FAU - Dougherty, Robert F
AU  - Dougherty RF
LA  - eng
GR  - K23 NS048302/NS/NINDS NIH HHS/United States
GR  - NS058899/NS/NINDS NIH HHS/United States
GR  - NS048302/NS/NINDS NIH HHS/United States
GR  - EY015000/EY/NEI NIH HHS/United States
GR  - HD047520/HD/NICHD NIH HHS/United States
GR  - K23 NS048302-04/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080409
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adult
MH  - Biological Clocks/*physiology
MH  - Brain/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Myelinated/*physiology/ultrastructure
MH  - Nerve Net/anatomy & histology/*physiology
MH  - Rest/*physiology
MH  - Young Adult
PMC - PMC2605172
MID - NIHMS74934
EDAT- 2008/04/12 09:00
MHDA- 2009/03/10 09:00
PMCR- 2010/01/01
CRDT- 2008/04/12 09:00
PHST- 2008/04/12 09:00 [entrez]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2009/03/10 09:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - bhn059 [pii]
AID - 10.1093/cercor/bhn059 [doi]
PST - ppublish
SO  - Cereb Cortex. 2009 Jan;19(1):72-8. doi: 10.1093/cercor/bhn059. Epub 2008 Apr 9.