PMID- 18404423
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1573-9538 (Print)
IS  - 1573-9546 (Electronic)
IS  - 1573-9538 (Linking)
VI  - 3
IP  - 1-2
DP  - 2007 Mar
TI  - Shaping immune responses through the activation of dendritic cells' P2 receptors.
PG  - 99-107
LID - 10.1007/s11302-006-9024-0 [doi]
AB  - Dendritic cells (DCs) activate and shape the adaptive immune response by 
      capturing antigens, migrating to peripheral lymphoid organs where naive T cells 
      reside, expressing high levels of MHC and costimulatory molecules and secreting 
      cytokines and chemokines. DCs are endowed with a high degree of functional 
      plasticity and their functions are tightly regulated. Besides initiating adaptive 
      immune responses, DCs play a key role in maintaining peripheral tolerance toward 
      self-antigens. On the basis of the information gathered from the tissue where 
      they reside, DCs adjust their functional activity to ensure that protective 
      immunity is favoured while unwanted or exaggerated immune responses are 
      prevented. A wide variety of signals from neighbouring cells affecting DC 
      functional activity have been described. Here we will discuss the complex role of 
      extracellular nucleotides in the regulation of DC function and the role of P2 
      receptors as possible tools to manipulate immune responses.
FAU - Ferrari, Davide
AU  - Ferrari D
AD  - Department of Experimental and Diagnostic Medicine, Section of General Pathology, 
      Interdisciplinary Center for the Study of Inflammation (ICSI), University of 
      Ferrara, Ferrara, Italy.
FAU - Gorini, Stefania
AU  - Gorini S
FAU - Callegari, Giulia
AU  - Callegari G
FAU - la Sala, Andrea
AU  - la Sala A
LA  - eng
PT  - Journal Article
DEP - 20060812
PL  - Netherlands
TA  - Purinergic Signal
JT  - Purinergic signalling
JID - 101250499
PMC - PMC2096769
EDAT- 2008/04/12 09:00
MHDA- 2008/04/12 09:01
PMCR- 2006/08/12
CRDT- 2008/04/12 09:00
PHST- 2006/02/06 00:00 [received]
PHST- 2006/06/19 00:00 [accepted]
PHST- 2006/05/30 00:00 [revised]
PHST- 2008/04/12 09:00 [pubmed]
PHST- 2008/04/12 09:01 [medline]
PHST- 2008/04/12 09:00 [entrez]
PHST- 2006/08/12 00:00 [pmc-release]
AID - 9024 [pii]
AID - 10.1007/s11302-006-9024-0 [doi]
PST - ppublish
SO  - Purinergic Signal. 2007 Mar;3(1-2):99-107. doi: 10.1007/s11302-006-9024-0. Epub 
      2006 Aug 12.