PMID- 18406209
OWN - NLM
STAT- MEDLINE
DCOM- 20080813
LR  - 20080502
IS  - 1471-4922 (Print)
IS  - 1471-4922 (Linking)
VI  - 24
IP  - 5
DP  - 2008 May
TI  - New insight into the role of dendritic cells in malaria immune pathogenesis.
PG  - 199-200
LID - 10.1016/j.pt.2008.02.003 [doi]
AB  - The mechanism by which the host develops protective immunity to malaria remains 
      poorly understood. Dendritic cells (DCs) are central to the initiation and 
      regulation of the adaptive immune response. Modulation of DC function might 
      enable Plasmodium to evade the immune system. Millington et al. propose one 
      mechanism by which malaria inhibits DC-T-cell interactions without interfering 
      directly with T-cell receptor engagement. The consequence is a decrease in the 
      co-stimulation required to develop an effective immune response.
FAU - Bousheri, Stephanie
AU  - Bousheri S
AD  - California Department of Public Health, Richmond, CA 94804, USA.
FAU - Cao, Huyen
AU  - Cao H
LA  - eng
PT  - Journal Article
DEP - 20080409
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/*parasitology
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
MH  - Malaria/*immunology/parasitology
MH  - Plasmodium/*immunology
MH  - T-Lymphocytes/immunology/parasitology
EDAT- 2008/04/15 09:00
MHDA- 2008/08/14 09:00
CRDT- 2008/04/15 09:00
PHST- 2008/01/16 00:00 [received]
PHST- 2008/02/17 00:00 [revised]
PHST- 2008/02/20 00:00 [accepted]
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/08/14 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
AID - S1471-4922(08)00084-6 [pii]
AID - 10.1016/j.pt.2008.02.003 [doi]
PST - ppublish
SO  - Trends Parasitol. 2008 May;24(5):199-200. doi: 10.1016/j.pt.2008.02.003. Epub 
      2008 Apr 9.