PMID- 18406398
OWN - NLM
STAT- MEDLINE
DCOM- 20081103
LR  - 20151119
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 64
IP  - 4
DP  - 2008 Aug 15
TI  - Low plasma brain-derived neurotrophic factor and childhood physical neglect are 
      associated with verbal memory impairment in major depression--a preliminary 
      report.
PG  - 281-5
LID - 10.1016/j.biopsych.2008.02.023 [doi]
AB  - BACKGROUND: Early life stress has been suggested to mediate vulnerability to 
      affective disorders. Animal models of repeated maternal separation have shown 
      reduced brain-derived neurotrophic factor (BDNF) levels in specific brain regions 
      implicated with hypothalamic-pituitary-adrenal axis and memory formation. In 
      addition, BDNF levels are also reduced in major depressive disorder (MDD) and 
      bipolar disorder. The aim of this study was to investigate whether childhood 
      physical neglect (CPN) and plasma BDNF levels would impact on memory performance 
      in adult female subjects with recurrent major depression. METHODS: Recurrent 
      female MDD outpatients with CPN (MDD + CPN, n = 17) and without CPN (MDD, n = 17) 
      and healthy control subjects (n = 15) were assessed for plasma BDNF content and 
      verbal memory performance. Memory was assessed through the logical memory 
      component of the Weschler Memory Scale-Revised for immediate and delayed recall. 
      Brain-derived neurotrophic factor was assessed with enzyme-linked immunosorbent 
      assays (ELISAs). RESULTS: Major depressive disorder patients showed lower plasma 
      BDNF concentrations than healthy control subjects (p < .001). Major depressive 
      disorder + CPN had even lower BDNF levels compared with control subjects and MDD 
      (p < .05). Brain-derived neurotrophic factor levels were negatively related to 
      psychological morbidity and positively correlated to memory performance. 
      Regression models showed that severity of self-reported CPN and low plasma BDNF 
      predicted impairment on immediate verbal recall. Delayed recall impairment was 
      predicted by severity of CPN and depression and memory retention by posttraumatic 
      stress disorder (PTSD) severity symptoms. CONCLUSIONS: Our data suggest that CPN 
      and plasma BDNF are important factors associated with depression and verbal 
      memory performance, particularly with encoding processes.
FAU - Grassi-Oliveira, Rodrigo
AU  - Grassi-Oliveira R
AD  - Faculty of Psychology, Pontifical Catholic University of Rio Grande do Sul 
      (PUCRS), Porto Alegre, Brazil.
FAU - Stein, Lilian Milnitsky
AU  - Stein LM
FAU - Lopes, Rodrigo Pestana
AU  - Lopes RP
FAU - Teixeira, Antonio L
AU  - Teixeira AL
FAU - Bauer, Moises Evandro
AU  - Bauer ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080411
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Abuse/*psychology
MH  - *Depressive Disorder, Major/blood/complications/etiology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Memory Disorders/*etiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Outpatients
MH  - Surveys and Questionnaires
MH  - Verbal Learning/*physiology
EDAT- 2008/04/15 09:00
MHDA- 2008/11/04 09:00
CRDT- 2008/04/15 09:00
PHST- 2007/10/05 00:00 [received]
PHST- 2008/01/29 00:00 [revised]
PHST- 2008/02/22 00:00 [accepted]
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/11/04 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
AID - S0006-3223(08)00298-9 [pii]
AID - 10.1016/j.biopsych.2008.02.023 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2008 Aug 15;64(4):281-5. doi: 10.1016/j.biopsych.2008.02.023. 
      Epub 2008 Apr 11.