PMID- 18407151
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20191027
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 4
IP  - 5
DP  - 1993 Jul
TI  - Regulation of retinoid and thyroid hormone action through homodimeric and 
      heterodimeric receptors.
PG  - 156-62
AB  - Biologic responses to retinoids and thyroid hormones are mediated by their 
      intracellular receptor proteins. Many exciting advances have been made recently 
      in understanding the molecular mechanism by which these receptor proteins 
      operate. In contrast to the steroid hormone receptors that function predominantly 
      as homodimers, thyroid hormone receptors (TRs)and retinoic acid receptors (RARs) 
      require interaction with the retinoid X receptors (RXRs) for efficient DNA 
      binding and transactivation. In addition, RXRs, in the presence of their specific 
      ligands such as 9-cis RA, can form homodimers that recognize a subset of retinoic 
      acid responsive elements (RAREs). The retinoid responses mediated by RXR 
      homodimers and RAR-RXR heterodimers can be restricted by the COUP-TF orphan 
      receptors that bind strongly to certain RAREs as homodimers. Thus, a complex 
      network of receptor interaction has been unraveled that promises a better 
      understanding of thyroid and retinoid hormone regulation of fundamental biologic 
      processes and diseases.
FAU - Zhang, X K
AU  - Zhang XK
AD  - Cancer Center, La Jolla Cancer Research Foundation, La Jolla, CA 92037, USA.
FAU - Kahl, M
AU  - Kahl M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 1043-2760(93)90105-N [pii]
AID - 10.1016/1043-2760(93)90105-n [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 1993 Jul;4(5):156-62. doi: 10.1016/1043-2760(93)90105-n.