PMID- 18407255
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20161124
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1210
DP  - 2008 May 19
TI  - Hyperbaric oxygen preconditioning induces tolerance against brain 
      ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.
PG  - 223-9
LID - 10.1016/j.brainres.2008.03.007 [doi]
AB  - The present study examined the hypothesis that cerebral ischemic tolerance 
      induced by hyperbaric oxygen preconditioning (HBO-PC) is associated with an 
      increase of antioxidant enzyme activity. Male Sprague-Dawley rats (250-280 g, 
      n=74) were divided into sham, middle cerebral artery occlusion (MCAO) for 90 min, 
      and MCAO plus HBO-PC groups. HBO-PC was conducted four times by given 100% oxygen 
      at 2.5 atmosphere absolute (ATA), for 1 h at every 12 h interval for 2 days. At 
      24 h after the last HBO-PC, MCAO was performed and at 24 h after MCAO, 
      neurological function and Nissl Staining were performed to evaluate the effect of 
      HBO-PC. Malondialdehyde (MDA) content, activity of catalase (CAT), superoxide 
      dismutase (SOD) and glutathione peroxidase (GSH-px) sampled from the hippocampus, 
      ischemic penumbra or core of cortex were measured. HBO-PC decreased mortality 
      rate, improved neurological recovery, lessened neuronal injury, reduced the level 
      of MDA and increased the antioxidant activity of CAT and SOD. These observations 
      demonstrated that an upregulation of the antioxidant enzyme activity by HBO 
      preconditioning plays an important role in the generation of tolerance against 
      brain ischemia-reperfusion injury.
FAU - Li, Jiasi
AU  - Li J
AD  - Department of Neurology, Changhai Hospital,174 Changhai Road, Shanghai 200433, PR 
      China.
FAU - Liu, Wenwu
AU  - Liu W
FAU - Ding, Suju
AU  - Ding S
FAU - Xu, Weigang
AU  - Xu W
FAU - Guan, Yangtai
AU  - Guan Y
FAU - Zhang, John H
AU  - Zhang JH
FAU - Sun, Xuejun
AU  - Sun X
LA  - eng
PT  - Journal Article
DEP - 20080312
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antioxidants)
RN  - 0 (Enzymes)
RN  - 0 (Reactive Oxygen Species)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Sod1 protein, rat)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
RN  - GAN16C9B8O (Glutathione)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Brain/enzymology
MH  - Brain Ischemia/*enzymology/therapy
MH  - Catalase/metabolism
MH  - Enzyme Activation
MH  - Enzymes/metabolism
MH  - Glutathione/metabolism
MH  - *Hyperbaric Oxygenation
MH  - Infarction, Middle Cerebral Artery/enzymology/therapy
MH  - *Ischemic Preconditioning
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - *Oxidative Stress
MH  - Oxygen/metabolism/pharmacology/therapeutic use
MH  - Oxygen Consumption/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reactive Oxygen Species/metabolism
MH  - Reperfusion Injury/*enzymology/therapy
MH  - Superoxide Dismutase/metabolism
MH  - Superoxide Dismutase-1
MH  - Up-Regulation
EDAT- 2008/04/15 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/04/15 09:00
PHST- 2008/01/27 00:00 [received]
PHST- 2008/03/03 00:00 [revised]
PHST- 2008/03/04 00:00 [accepted]
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
AID - S0006-8993(08)00617-3 [pii]
AID - 10.1016/j.brainres.2008.03.007 [doi]
PST - ppublish
SO  - Brain Res. 2008 May 19;1210:223-9. doi: 10.1016/j.brainres.2008.03.007. Epub 2008 
      Mar 12.