PMID- 18407554
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20211020
IS  - 1058-8388 (Print)
IS  - 1097-0177 (Electronic)
IS  - 1058-8388 (Linking)
VI  - 237
IP  - 8
DP  - 2008 Aug
TI  - Identification of genes involved in the ciliary trafficking of C. elegans PKD-2.
PG  - 2021-9
LID - 10.1002/dvdy.21531 [doi]
AB  - Ciliary membrane proteins are important extracellular sensors, and defects in 
      their localization may have profound developmental and physiological 
      consequences. To determine how sensory receptors localize to cilia, we performed 
      a forward genetic screen and identified 11 mutants with defects in the ciliary 
      localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin 
      (TRPP) channel. Class A cil mutants exhibit defects in PKD-2::GFP somatodendritic 
      localization while Class B cil mutants abnormally accumulate PKD-2::GFP in cilia. 
      Further characterization reveals that some genes mutated in cil mutants act in a 
      tissue-specific manner while others are likely to play more general roles in such 
      processes as intraflagellar transport (IFT). To this end, we identified a Class B 
      mutation that disrupts the function of the cytoplasmic dynein light intermediate 
      chain gene xbx-1. Identification of the remaining mutations will reveal novel 
      molecular pathways required for ciliary receptor localization and provide further 
      insight into mechanisms of ciliary signaling.
CI  - Copyright (c) 2008 Wiley-Liss, Inc.
FAU - Bae, Young-Kyung
AU  - Bae YK
AD  - Department of Genetics, Rutgers University, The State University of New Jersey, 
      Piscataway, New Jersey 08854, USA.
FAU - Lyman-Gingerich, Jamie
AU  - Lyman-Gingerich J
FAU - Barr, Maureen M
AU  - Barr MM
FAU - Knobel, Karla M
AU  - Knobel KM
LA  - eng
GR  - R01 DK059418/DK/NIDDK NIH HHS/United States
GR  - R01 DK059418-06A1/DK/NIDDK NIH HHS/United States
GR  - R01 DK059418-07/DK/NIDDK NIH HHS/United States
GR  - R01 DK059418-08/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of 
      Anatomists
JID - 9201927
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (PKD-2 protein, C elegans)
RN  - 0 (TRPP Cation Channels)
RN  - EC 3.6.4.2 (Dyneins)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/*genetics
MH  - Caenorhabditis elegans Proteins/*genetics/*metabolism
MH  - Chromosome Mapping
MH  - Cilia/pathology/*physiology
MH  - Dendrites/physiology
MH  - Dyneins/genetics/metabolism
MH  - Genetic Testing
MH  - Mutation
MH  - Neurons, Afferent/physiology/ultrastructure
MH  - Phenotype
MH  - Protein Transport/*genetics
MH  - Reproduction/physiology
MH  - Signal Transduction/genetics
MH  - TRPP Cation Channels/*metabolism
PMC - PMC3118579
MID - NIHMS287354
EDAT- 2008/04/15 09:00
MHDA- 2008/10/24 09:00
PMCR- 2011/06/20
CRDT- 2008/04/15 09:00
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
PHST- 2011/06/20 00:00 [pmc-release]
AID - 10.1002/dvdy.21531 [doi]
PST - ppublish
SO  - Dev Dyn. 2008 Aug;237(8):2021-9. doi: 10.1002/dvdy.21531.