PMID- 18407596
OWN - NLM
STAT- MEDLINE
DCOM- 20080814
LR  - 20211020
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 14
IP  - 14
DP  - 2008 Apr 14
TI  - Thrombospondin-1 expression correlates with angiogenesis in experimental 
      cirrhosis.
PG  - 2213-7
AB  - AIM: To investigate the significance of Thrombospondin-1 (TSP-1) expression and 
      its relationship with angiogenesis during experimental fibrosis. METHODS: 
      Cirrhosis was induced in male Wistar rats by intraperitoneal administration of 
      diethyl nitrosamine (DEN). The serial sections from liver tissues were stained 
      with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light 
      microscopy. RESULTS: Our results showed that of TSP-1 expression gradually 
      increases according to the severity of fibrosis (P < 0.05). Moreover, TSP-1 
      expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION: 
      The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis 
      provided by this study suggests that besides its role as a strong promoter of 
      transforming growth factor-beta 1 (TGF-beta 1), TSP-1 might have an additional 
      role in liver fibrogenesis by stimulating angiogenesis and this protein could be 
      a potential target to prevent fibrogenesis in chronic inflammatory diseases of 
      the liver.
FAU - Elpek, Gulsum-Ozlem
AU  - Elpek GO
AD  - Akdeniz University, Medical School, Department of Pathology, Antalya 07070, 
      Turkey.
FAU - Gokhan, Guzide-Ayse
AU  - Gokhan GA
FAU - Bozova, Sevgi
AU  - Bozova S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Antigens, CD34)
RN  - 0 (Thrombospondin 1)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
SB  - IM
MH  - Animals
MH  - Antigens, CD34/biosynthesis
MH  - Diethylnitrosamine/metabolism
MH  - Disease Models, Animal
MH  - Fibrosis/*metabolism
MH  - *Gene Expression Regulation
MH  - Immunohistochemistry/methods
MH  - Inflammation
MH  - Liver/pathology
MH  - Male
MH  - *Neovascularization, Pathologic
MH  - Rats
MH  - Rats, Wistar
MH  - Thrombospondin 1/*biosynthesis
PMC - PMC2703847
EDAT- 2008/04/15 09:00
MHDA- 2008/08/15 09:00
PMCR- 2008/04/14
CRDT- 2008/04/15 09:00
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/08/15 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
PHST- 2008/04/14 00:00 [pmc-release]
AID - 10.3748/wjg.14.2213 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2008 Apr 14;14(14):2213-7. doi: 10.3748/wjg.14.2213.