PMID- 18408419
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20080514
IS  - 1423-033X (Electronic)
IS  - 0254-4962 (Linking)
VI  - 41
IP  - 4
DP  - 2008
TI  - Potential vulnerability markers within the affective domain in subjects at 
      genetic and clinical high risk for schizophrenia.
PG  - 236-44
LID - 10.1159/000125557 [doi]
AB  - BACKGROUND: Relative to ample high-risk studies on neurocognitive function, only 
      a few high-risk studies have examined affective functioning components as 
      possible vulnerability markers. In this study, we comprehensively assessed 
      baseline affective functioning in subjects at clinical high risk (CHR) and 
      genetic high risk (GHR) for schizophrenia, and healthy controls (HC), and 
      compared the results to elucidate possible vulnerability markers in the affective 
      domain. METHODS: We studied 3 groups of subjects: those with CHR (n = 28) or GHR 
      (n = 28) and a HC group (n = 24). Affective-process- and 
      affective-content-related functioning were assessed using 5 emotion-related 
      scales. RESULTS: In affective process, CHR subjects showed impairments in 
      emotional awareness and mood repair, with some trend of impaired emotional 
      expressivity as well as aggression control relative to either HC or GHR subjects, 
      whereas GHR subjects showed only a trend of impairment in mood repair. In 
      affective content, CHR subjects had less positive and more negative affect scores 
      than the other 2 groups. CONCLUSIONS: These results correspond to previous 
      findings of prodrome studies of schizophrenia and chronic schizophrenia and 
      suggest that impaired mood repair and emotional awareness, as well as less 
      positive and more negative affect may be potential candidates of vulnerability 
      markers.
CI  - (c) 2008 S. Karger AG, Basel
FAU - Lee, Seung Jae
AU  - Lee SJ
AD  - Department of Neuropsychiatry, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Yoo, So Young
AU  - Yoo SY
FAU - Kang, Do-Hyung
AU  - Kang DH
FAU - Lee, Kyung Jin
AU  - Lee KJ
FAU - Ha, Tae Hyun
AU  - Ha TH
FAU - Wee, Whee
AU  - Wee W
FAU - Lee, Ae-Ra
AU  - Lee AR
FAU - Kim, Nam Sick
AU  - Kim NS
FAU - Kwon, Jun Soo
AU  - Kwon JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080411
PL  - Switzerland
TA  - Psychopathology
JT  - Psychopathology
JID - 8401537
SB  - IM
MH  - Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Affect
MH  - Affective Symptoms/diagnosis/*genetics/psychology
MH  - Awareness
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease/genetics/psychology
MH  - Humans
MH  - Male
MH  - Personality Inventory
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnosis/*genetics
MH  - *Schizophrenic Psychology
MH  - Schizotypal Personality Disorder/diagnosis/genetics/psychology
EDAT- 2008/04/15 09:00
MHDA- 2008/07/09 09:00
CRDT- 2008/04/15 09:00
PHST- 2006/11/07 00:00 [received]
PHST- 2007/07/03 00:00 [accepted]
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
AID - 000125557 [pii]
AID - 10.1159/000125557 [doi]
PST - ppublish
SO  - Psychopathology. 2008;41(4):236-44. doi: 10.1159/000125557. Epub 2008 Apr 11.