PMID- 18408624
OWN - NLM
STAT- MEDLINE
DCOM- 20080813
LR  - 20221207
IS  - 1744-6872 (Print)
IS  - 1744-6872 (Linking)
VI  - 18
IP  - 6
DP  - 2008 Jun
TI  - BDNF gene is a genetic risk factor for schizophrenia and is related to the 
      chlorpromazine-induced extrapyramidal syndrome in the Chinese population.
PG  - 449-57
LID - 10.1097/FPC.0b013e3282f85e26 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) belongs to a family of the 
      neurotrophin, which plays important roles in the neurodevelopment of 
      dopaminergic-related systems and interacts with meso-limbic dopaminergic systems 
      involved in the therapeutic response to antipsychotics. Functional experiments 
      have suggested that BDNF may be involved in the etiology of schizophrenia. 
      METHODS AND RESULTS: In this study, we genotyped two important functional 
      polymorphisms in the BDNF gene using a sample of Han Chinese patients consisting 
      of 340 schizophrenic patients and 343 healthy controls. We found a statistical 
      difference in the 232-bp allele distribution of the BDNF gene (GT)n dinucleotide 
      repeat polymorphism between the schizophrenic patients and controls. In early 
      onset patients, the 234-bp allele had a risk role. For the chlorpromazine-induced 
      extrapyramidal syndrome, the 230-bp allele and the 234-bp allele acted in 
      opposite directions, that is, patients with the 230-bp allele of the (GT)n 
      polymorphism exhibited a lower degree of induced extrapyramidal syndrome. 
      Haplotype-based analysis also revealed a very important risk haplotype 
      (P=0.0000226546). CONCLUSION: These findings suggest that BDNF plays an important 
      role in the susceptibility to schizophrenia and that the (GT)n repeat 
      polymorphism of the BDNF gene may be an independent contributor to the 
      chlorpromazine treatment-sensitive form of schizophrenia.
FAU - Xu, Ming-Qing
AU  - Xu MQ
AD  - Bio-X Life Science Research Centre, Shanghai Jiao Tong University, PR China. 
      mingqingxu@gmail.com
FAU - St Clair, David
AU  - St Clair D
FAU - Feng, Guo-Yin
AU  - Feng GY
FAU - Lin, Zhi-Guang
AU  - Lin ZG
FAU - He, Guang
AU  - He G
FAU - Li, Xingwang
AU  - Li X
FAU - He, Lin
AU  - He L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacogenet Genomics
JT  - Pharmacogenetics and genomics
JID - 101231005
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antipsychotic Agents/*adverse effects
MH  - Asian People/*genetics
MH  - Basal Ganglia Diseases/*chemically induced/*genetics
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Chlorpromazine/*adverse effects
MH  - DNA Primers/genetics
MH  - Dinucleotide Repeats
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pharmacogenetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Schizophrenia/*drug therapy/*genetics
MH  - Syndrome
EDAT- 2008/04/15 09:00
MHDA- 2008/08/14 09:00
CRDT- 2008/04/15 09:00
PHST- 2008/04/15 09:00 [pubmed]
PHST- 2008/08/14 09:00 [medline]
PHST- 2008/04/15 09:00 [entrez]
AID - 10.1097/FPC.0b013e3282f85e26 [doi]
PST - ppublish
SO  - Pharmacogenet Genomics. 2008 Jun;18(6):449-57. doi: 10.1097/FPC.0b013e3282f85e26.