PMID- 1841030
OWN - NLM
STAT- MEDLINE
DCOM- 19921026
LR  - 20221207
IS  - 0265-5985 (Print)
IS  - 0265-5985 (Linking)
VI  - 17
IP  - 3
DP  - 1991 Jul
TI  - The effects of overeating on insulin secretion in normal mice.
PG  - 139-45
AB  - This study was performed to examine the effect of overeating on in vivo and in 
      vitro insulin secretion in normal mice. Six week old male CRJ-ICR mice were 
      maintained on a cookie and chocolate mashed diet (C.C. diet) until 30 weeks of 
      age; control mice received an ordinary mouse chow. The mice on the C.C. diet 
      (C.C. mice) consumed 125-130% of the daily caloric intake of control mice 
      throughout the study. C.C. mice developed mild hyperglycemia with relative 
      obesity from 16 weeks of age. Fed blood glucose levels at 30 weeks of age for 
      C.C. mice were 158.3 +/- 6.7 mg/dl as opposed to 127.2 +/- 3.1 mg/dl for controls 
      (p less than 0.01). In experimental mice at 18 weeks of age, plasma insulin 
      response after intraperitoneal glucose load (2 mg/g BW) and insulin secretion at 
      30 mM glucose from the perfused pancreas were similar to those in control mice. 
      However, at 30 weeks of age, insulin secretion at 30 mM glucose from perfused 
      pancreas in C.C. mice was significantly suppressed compared with that of control 
      mice (p less than 0.02). Conversely, in vivo insulin secretory response to 
      intraperitoneal glucose load was significantly increased in C.C. mice (p less 
      than 0.05). There were no differences in insulin secretion at 15 mM glucose from 
      perfused pancreas. These results indicate that impairment of beta-cell secretory 
      capacity develops in impaired glucose tolerant mice with obesity, while in vivo 
      studies show a high insulin response to glucose. This alteration of beta-cell 
      function may be the initial change during the development of the 
      hyperglycemia-induced defect in insulin secretion.
FAU - Hasegawa, G
AU  - Hasegawa G
AD  - Department of Internal Medicine, Ayabe Municipal Hospital, Kyoto, Japan.
FAU - Sawada, M
AU  - Sawada M
FAU - Nakamura, N
AU  - Nakamura N
FAU - Nakano, K
AU  - Nakano K
FAU - Kondo, M
AU  - Kondo M
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Diabetes Res
JT  - Diabetes research (Edinburgh, Scotland)
JID - 8502339
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 94ZLA3W45F (Arginine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Arginine/pharmacology
MH  - Blood Glucose/*metabolism
MH  - Body Weight
MH  - Cacao
MH  - *Diet
MH  - Feeding and Eating Disorders/*physiopathology
MH  - Glucose/pharmacology
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - Islets of Langerhans/drug effects/growth & development/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Perfusion
MH  - Reference Values
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
PST - ppublish
SO  - Diabetes Res. 1991 Jul;17(3):139-45.