PMID- 18411705
OWN - NLM
STAT- MEDLINE
DCOM- 20080530
LR  - 20161124
IS  - 1340-2544 (Print)
IS  - 1340-2544 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Feb
TI  - [Minocycline as a therapeutic drug for methamphetamine use disorders].
PG  - 19-22
AB  - Use of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) is an 
      extremely serious and growing problem throughout the world, including Japan. 
      Antipsychotic drugs have been used for psychotic symptoms associated with these 
      abused drugs. However, there are currently no particular pharmacological 
      treatments for the wide range of symptoms associated with these abused drugs. 
      Recently, we reported that the second generation antibiotic drug minocycline can 
      attenuate behavioral abnormalities and neurotoxicity in the brain after 
      administration of methamphetamine or MDMA. In this review, we discuss minocycline 
      as a new potential therapeutic drug for schizophrenia as well as psychosis 
      associated with these abused drugs.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, 1-8-1 Inohana, Chiba, 260-8670 Japan. hashimoto@faculty.chiba-u.jp
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Shinkei Seishin Yakurigaku Zasshi
JT  - Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology
JID - 9509023
RN  - 0 (Anti-Bacterial Agents)
RN  - 44RAL3456C (Methamphetamine)
RN  - FYY3R43WGO (Minocycline)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Brain/diagnostic imaging
MH  - Disease Models, Animal
MH  - Humans
MH  - Methamphetamine/*adverse effects
MH  - Minocycline/*therapeutic use
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Positron-Emission Tomography
MH  - Psychoses, Substance-Induced/diagnostic imaging/*drug therapy/etiology
MH  - Schizophrenia/drug therapy
MH  - Substance-Related Disorders/diagnostic imaging/*drug therapy/etiology
RF  - 40
EDAT- 2008/04/17 09:00
MHDA- 2008/05/31 09:00
CRDT- 2008/04/17 09:00
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2008/05/31 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
PST - ppublish
SO  - Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Feb;28(1):19-22.