PMID- 18412610
OWN - NLM
STAT- MEDLINE
DCOM- 20080701
LR  - 20080416
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 27
IP  - 8
DP  - 2008 Apr
TI  - Regulation of neurofilament dynamics by phosphorylation.
PG  - 1893-901
LID - 10.1111/j.1460-9568.2008.06165.x [doi]
AB  - Neurofilament (NF) phosphorylation has long been considered to regulate axonal 
      transport rate and in doing so to provide stability to mature axons. Studies 
      utilizing mice in which the C-terminal region of NF subunits (which contains the 
      vast majority of phosphorylation sites) has been deleted has prompted an ongoing 
      challenge to this hypothesis. We evaluate the collective evidence to date for and 
      against a role for NF C-terminal phosphorylation in regulation of axonal 
      transport and in providing structural support for axons, including some novel 
      studies from our laboratory. We present a few suggestions for further 
      experimentation in this area, and expand upon previous models for axonal NF 
      dynamics. Finally, we address how C-terminal phosphorylation is regionally and 
      temporally regulated by a balance of kinase and phosphatase activities, and how 
      misregulation of this balance can contribute to motor neuron disease.
FAU - Shea, Thomas B
AU  - Shea TB
AD  - Center for Cellular Neurobiology and Neurodegeneration Research, Department of 
      Biological Sciences, University of Massachusetts Lowell, One University Avenue, 
      Lowell, MA 01854, USA. Thomas_Shea@uml.edu
FAU - Chan, Walter K-H
AU  - Chan WK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Neurofilament Proteins)
SB  - IM
MH  - Animals
MH  - Axonal Transport/*physiology
MH  - Humans
MH  - Neurofilament Proteins/*metabolism
MH  - *Phosphorylation
RF  - 72
EDAT- 2008/04/17 09:00
MHDA- 2008/07/02 09:00
CRDT- 2008/04/17 09:00
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2008/07/02 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
AID - EJN6165 [pii]
AID - 10.1111/j.1460-9568.2008.06165.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2008 Apr;27(8):1893-901. doi: 10.1111/j.1460-9568.2008.06165.x.