PMID- 18413153
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20131121
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 23
IP  - 3
DP  - 2009 May-Jun
TI  - The effect of simvastatin on the serum monocyte chemoattractant protein-1 and 
      intracellular adhesion molecule-1 levels in diabetic rats.
PG  - 214-8
LID - 10.1016/j.jdiacomp.2007.09.003 [doi]
AB  - OBJECTIVE: This study aimed to observe the effect of simvastatin on the serum 
      monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 
      (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in 
      diabetic rats. METHODS: Twenty-four Wistar rats were randomly assigned to a 
      normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, 
      n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C 
      were treated with simvastatin (20 mg kg(-1) day(-1)) 1 week after the 
      establishment of the diabetic model. Groups A and B were treated with 
      corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum 
      MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week. RESULTS: At the 
      second, fourth, and eighth week, peripheral blood glucose levels in Group B were 
      similar to those of Group C, which were much higher than those of Group A. Serum 
      MCP-1 and ICAM-1 levels in Groups B and C were higher than those of Group A 
      (P<.01), and serum MCP-1 and ICAM-1 levels in Group C were lower than those of 
      Group B (P<.01); HbA1c was not significantly different between Group C and Group 
      B. CONCLUSION: Simvastatin has the effect of anti-inflammation, which may play 
      some protection against the progress of atherosclerosis in diabetic rats.
FAU - Lin, Yang
AU  - Lin Y
AD  - Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui 
      Medical University, Hefei, 230001, China.
FAU - Ye, Shandong
AU  - Ye S
FAU - Chen, Yan
AU  - Chen Y
FAU - Li, Xiucai
AU  - Li X
FAU - Yang, Guang-wei
AU  - Yang GW
FAU - Fan, Aihong
AU  - Fan A
FAU - Wang, Yingxin
AU  - Wang Y
LA  - eng
PT  - Journal Article
DEP - 20080416
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Chemokine CCL2)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*blood
MH  - Diabetes Mellitus, Experimental/*blood/chemically induced
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Simvastatin/pharmacology
EDAT- 2008/04/17 09:00
MHDA- 2009/08/04 09:00
CRDT- 2008/04/17 09:00
PHST- 2007/07/28 00:00 [received]
PHST- 2007/09/06 00:00 [accepted]
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
AID - S1056-8727(07)00109-2 [pii]
AID - 10.1016/j.jdiacomp.2007.09.003 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2009 May-Jun;23(3):214-8. doi: 
      10.1016/j.jdiacomp.2007.09.003. Epub 2008 Apr 16.