PMID- 18413177
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20081201
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 23
IP  - 1
DP  - 2009 Jan-Feb
TI  - Endothelial dysfunction and history of recurrent depression in postmenopausal 
      women with Type 2 diabetes: a case-control study.
PG  - 18-24
LID - 10.1016/j.jdiacomp.2007.11.007 [doi]
AB  - OBJECTIVES: This study of postmenopausal women with Type 2 diabetes mellitus 
      (T2DM) investigated (1) history of depression as a predictor of 
      endothelium-dependent flow-mediated dilation (FMD); (2) the relative associations 
      of single and recurrent depressive disorders with FMD; and (3) cortisol as a 
      potential mechanism. METHODS: Participants were nonsmoking, naturally 
      postmenopausal women with T2DM with no known vascular disease. All were free of 
      current mood disorder. On average, the 44 participants were 63 years of age, 
      White, diabetic for 6 years, and were in adequate glycemic control. Thirty-eight 
      percent were never depressed, 19% had experienced one disorder, and 43% had 
      experienced recurrent disorders. History of depression was assessed with 
      Structured Clinical Interview for Diagnostic and Statistical Manual-IV. Current 
      depressive symptoms were measured with Center for Epidemiological Studies 
      Depression (CESD) scale. FMD was assessed by standard procedures and calculated 
      as percent change in brachial artery diameter from baseline. RESULTS: Women with 
      history of recurrent depression showed vasoconstriction (mean=-1%), which was 
      significantly different from women with history of single depression (mean=+6) 
      and never depressed women (mean=+5) (P<.05), both of whom showed similar levels 
      of vasodilation. In logistic regression controlling for hypertension, duration of 
      diabetes, and glycemic control, history of recurrent depressive disorders 
      predicted greater likelihood of vasoconstriction (P<.05, odds ratio=4.23) but 
      history of single depressive disorder did not. Controlling for current depressive 
      symptoms did not account for effects of past recurrent depressive disorders. 
      Cortisol was not related to FMD. CONCLUSIONS: In postmenopausal women with T2DM, 
      recurrent depressive disorders, even in full remission, are associated with 
      endothelial dysfunction. Potential mechanisms of the relationship between 
      depression and endothelial dysfunction other than cortisol warrant investigation.
FAU - Wagner, Julie
AU  - Wagner J
AD  - Department of Behavioral Sciences and Community Health, University of Connecticut 
      Health Center, MC3910, Farmington, CT 06030, USA. juwagner@uchc.edu
FAU - Tennen, Howard
AU  - Tennen H
FAU - Mansoor, George
AU  - Mansoor G
FAU - Abbott, Gina
AU  - Abbott G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080416
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Depression/blood/*complications/*psychology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Endothelium/*physiopathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Postmenopause/*psychology
MH  - Recurrence
EDAT- 2008/04/17 09:00
MHDA- 2009/02/05 09:00
CRDT- 2008/04/17 09:00
PHST- 2007/02/18 00:00 [received]
PHST- 2007/10/12 00:00 [revised]
PHST- 2007/11/09 00:00 [accepted]
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
AID - S1056-8727(07)00141-9 [pii]
AID - 10.1016/j.jdiacomp.2007.11.007 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2009 Jan-Feb;23(1):18-24. doi: 
      10.1016/j.jdiacomp.2007.11.007. Epub 2008 Apr 16.