PMID- 18413224
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20211020
IS  - 1056-8727 (Print)
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 22
IP  - 3
DP  - 2008 May-Jun
TI  - Association of insulin sensitivity and glucose tolerance with the c.825C>T 
      variant of the G protein beta-3 subunit gene.
PG  - 205-9
LID - 10.1016/j.jdiacomp.2006.12.005 [doi]
AB  - The risk of macrovascular complications of diabetes mellitus is greatly enhanced 
      by the presence of high blood pressure. In addition, hypertension and diabetes 
      share insulin resistance as a common pathophysiological mechanism. Despite 
      evidence for a common molecular genetic background of insulin resistance, glucose 
      intolerance, and hypertension, few candidate genes have been shown to influence 
      all of these features simultaneously. We examined the association of insulin 
      sensitivity with the c.825C>T variant of the g-protein beta-3 subunit (GNB3), a 
      candidate gene of hypertension, in families of Mexican-American hypertensive 
      patients. METHODS: One hundred eighty subjects enrolled in a family study of 
      Mexican-American hypertensive patients were recruited from hypertension clinics 
      in Los Angeles. Subjects underwent pretreatment blood pressure recording, an oral 
      glucose tolerance test, euglycemic hyperinsulinemic clamp, and anthropometric 
      measurements. DNA from peripheral blood leukocytes was genotyped by polymerase 
      chain reaction and restriction enzyme digest with BseD1 (GNB). Statistical 
      analysis was performed by transmission disequilibrium testing. RESULTS: In 
      carriers of the T-allele, blood glucose was significantly lower [(mean+S.D.) 
      fasting: 96.7+22.9 vs. 106.7+51.7mg/dl, P=.009; oral glucose tolerance test 
      (oGTT) 120 min: 131.7+48.7 vs. 137.8+64.9 mg/dl, P=.036], and insulin sensitivity 
      was significantly higher (229.0+108.7 vs. 188.5+94.2 mg/kg per minute, P=.037) 
      than in homozygous carriers of the C-allele. Blood pressure did not differ 
      significantly between the phenotypes. CONCLUSION: In a Mexican-American 
      hypertensive population, we found evidence for higher insulin sensitivity in 
      carriers of the T allele of the c.825C>T variant of GNB3.
FAU - Kopf, Daniel
AU  - Kopf D
AD  - Department of Endocrinology and Metabolism, University of Magdeburg, Magdeburg, 
      Germany. kopf@zi-mannheim.de
FAU - Cheng, Li S-C
AU  - Cheng LS
FAU - Blandau, Petra
AU  - Blandau P
FAU - Hsueh, Willa
AU  - Hsueh W
FAU - Raffel, Leslie J
AU  - Raffel LJ
FAU - Buchanan, Thomas A
AU  - Buchanan TA
FAU - Xiang, Anny H
AU  - Xiang AH
FAU - Davis, Richard C
AU  - Davis RC
FAU - Rotter, Jerome I
AU  - Rotter JI
FAU - Lehnert, Hendrik
AU  - Lehnert H
LA  - eng
GR  - P50 HL055005-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL088457/HL/NHLBI NIH HHS/United States
GR  - R01 HL088457-01/HL/NHLBI NIH HHS/United States
GR  - R01 HL088457-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20080416
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Blood Glucose)
RN  - 0 (GTP-Binding Protein beta Subunits)
RN  - 0 (Insulin)
RN  - 8J337D1HZY (Cytosine)
RN  - QR26YLT7LT (Thymine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Cytosine
MH  - Female
MH  - GTP-Binding Protein beta Subunits/*genetics
MH  - *Genetic Variation
MH  - Glucose Clamp Technique
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypertension/genetics
MH  - Insulin/*pharmacology
MH  - Male
MH  - Mexican Americans/genetics
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Thymine
MH  - Waist-Hip Ratio
PMC - PMC2695761
MID - NIHMS50784
EDAT- 2008/04/17 09:00
MHDA- 2008/08/30 09:00
PMCR- 2009/06/12
CRDT- 2008/04/17 09:00
PHST- 2006/10/07 00:00 [received]
PHST- 2006/11/17 00:00 [revised]
PHST- 2006/12/19 00:00 [accepted]
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
PHST- 2009/06/12 00:00 [pmc-release]
AID - S1056-8727(07)00010-4 [pii]
AID - 10.1016/j.jdiacomp.2006.12.005 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2008 May-Jun;22(3):205-9. doi: 
      10.1016/j.jdiacomp.2006.12.005. Epub 2008 Apr 16.