PMID- 18413422
OWN - NLM
STAT- MEDLINE
DCOM- 20080821
LR  - 20220410
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 93
IP  - 7
DP  - 2008 Jul
TI  - Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in 
      conditions of mild iodine deficiency.
PG  - 2616-21
LID - 10.1210/jc.2008-0352 [doi]
AB  - CONTEXT: Mild to moderate iodine deficiency during pregnancy can cause transient 
      maternal hypothyroidism and impaired mental development of the progeny. These 
      unfavorable effects are preventable by iodine supplementation. In Europe, 
      however, less than 50% pregnant women receive iodine-containing supplements, thus 
      representing dietary iodized salt the only carrier of iodine for most women in 
      this life stage. OBJECTIVE/DESIGN: This longitudinal study is aimed to 
      investigate the effects of long-term iodized salt consumption on maternal thyroid 
      function during gestation. PARTICIPANTS/OUTCOME MEASURES: We prospectively 
      evaluated thyroid function in 100 consecutive thyroperoxidase antibody-negative 
      pregnant women from a mildly iodine-deficient area. Sixty-two women who had 
      regularly used iodized salt for at least 2 yr prior to becoming pregnant and 38 
      who commenced iodized salt consumption upon becoming pregnant were classified as 
      long-term (LT) and short-term (ST) iodine supplemented, respectively. RESULTS: 
      Long-term iodized salt consumption resulted in a very low prevalence of maternal 
      thyroid failure (MTF) in LT women. Conversely, short-term iodine prophylaxis does 
      not seem to protect against the risk of MTF, the prevalence of which was almost 
      6-fold higher in ST than LT women (36.8% vs. 6.4%; chi(2) 14.7, P < 0.0005; 
      relative risk 5.7, 95% confidence interval 2.03-16.08, P < 0.001). The relative 
      risk reduction amounted to 82.5%, this measure indicating the extent to which 
      long-term iodine prophylaxis using iodized salt would reduce the risk of MTF in 
      ST women. CONCLUSIONS: Prolonged iodized salt significantly improves maternal 
      thyroid economy and reduces the risk of maternal thyroid insufficiency during 
      gestation, probably because of a nearly restoring intrathyroidal iodine stores.
FAU - Moleti, Mariacarla
AU  - Moleti M
AD  - Cattedra di Endocrinologia, Policlinico Universitario, Via Consolare Valeria, 
      98125 Messina, Italy.
FAU - Lo Presti, Vincenzo Pio
AU  - Lo Presti VP
FAU - Campolo, Maria Cristina
AU  - Campolo MC
FAU - Mattina, Filiberto
AU  - Mattina F
FAU - Galletti, Marina
AU  - Galletti M
FAU - Mandolfino, Mattia
AU  - Mandolfino M
FAU - Violi, Maria Antonia
AU  - Violi MA
FAU - Giorgianni, Grazia
AU  - Giorgianni G
FAU - De Domenico, Demetrio
AU  - De Domenico D
FAU - Trimarchi, Francesco
AU  - Trimarchi F
FAU - Vermiglio, Francesco
AU  - Vermiglio F
LA  - eng
PT  - Journal Article
DEP - 20080415
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (iodized salt)
RN  - 9010-34-8 (Thyroglobulin)
RN  - 9679TC07X4 (Iodine)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
CIN - J Clin Endocrinol Metab. 2008 Jul;93(7):2466-8. PMID: 18617699
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypothyroidism/etiology/*prevention & control
MH  - Iodine/administration & dosage/*deficiency
MH  - Pregnancy
MH  - Pregnancy Complications/etiology/*prevention & control
MH  - Prospective Studies
MH  - Sodium Chloride, Dietary/*administration & dosage
MH  - Thyroglobulin/blood
MH  - Thyroxine/blood
EDAT- 2008/04/17 09:00
MHDA- 2008/08/22 09:00
CRDT- 2008/04/17 09:00
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2008/08/22 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
AID - jc.2008-0352 [pii]
AID - 10.1210/jc.2008-0352 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2008 Jul;93(7):2616-21. doi: 10.1210/jc.2008-0352. Epub 
      2008 Apr 15.