PMID- 18414431
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20180822
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 86
IP  - 5
DP  - 2008 Jul
TI  - Probing in vivo dendritic cell functions by conditional cell ablation.
PG  - 409-15
LID - 10.1038/icb.2008.23 [doi]
AB  - Dendritic cells (DCs) play a central role in T-cell activation and the control of 
      the inherent autoreactivity of the T-cell compartment. Pleiotropic DC functions 
      are likely associated with discrete DC subsets. However, the latter remain 
      largely defined by phenotype and unique anatomic location, rather than function. 
      The investigation of DC involvement in complex phenomena that rely on 
      multicellular interactions, such as immuno-stimulation and tolerization calls for 
      an assessment of DC functions within physiological context. Given the highly 
      dynamic DC compartment, the method of choice to study in vivo DC functions is 
      their conditional ablation in the intact organism. Here, we summarize the recent 
      progress in this field highlighting pitfalls and prospects of the approach.
FAU - Sapoznikov, Anita
AU  - Sapoznikov A
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Jung, Steffen
AU  - Jung S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20080415
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (CD11c Antigen)
RN  - 0 (Heparin-binding EGF-like Growth Factor)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - CD11c Antigen/genetics/immunology/metabolism
MH  - Cell Death/immunology
MH  - Dendritic Cells/*cytology/*immunology
MH  - Heparin-binding EGF-like Growth Factor
MH  - Intercellular Signaling Peptides and Proteins/genetics/metabolism
RF  - 96
EDAT- 2008/04/17 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/04/17 09:00
PHST- 2008/04/17 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/04/17 09:00 [entrez]
AID - icb200823 [pii]
AID - 10.1038/icb.2008.23 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2008 Jul;86(5):409-15. doi: 10.1038/icb.2008.23. Epub 2008 Apr 
      15.