PMID- 18416774
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20220316
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 5
DP  - 2008 May
TI  - HLA-DRB1 alleles influence clinical phenotypes in Japanese patients with 
      ulcerative colitis.
PG  - 447-52
LID - 10.1111/j.1399-0039.2008.01031.x [doi]
AB  - The human leukocyte antigen (HLA) region has been implicated in the disease 
      susceptibility of inflammatory bowel disease by several linkage and association 
      studies. In Caucasians, HLA-DRB1 has been reported to determine the clinical 
      phenotypes of ulcerative colitis (UC). Others and we previously reported that 
      HLA-DRB1*1502 was strongly associated with UC in the Japanese population. 
      However, the contribution of HLA-DRB1 to the clinical phenotypes in Japanese UC 
      has not been elucidated yet. The aim of this study was to determine whether 
      HLA-DRB1 alleles were associated with the clinical phenotypes in Japanese 
      patients with UC. A total of 353 patients with UC were recruited. Patients were 
      classified into subgroups by sex, age at diagnosis, disease extent, need for 
      steroid therapy or need for surgical treatment. The allele frequency of 
      HLA-DRB1*08 was significantly higher in patients whose disease extended beyond 
      the rectum (left-sided and extensive UC) than in those with proctitis [odds ratio 
      (OR)=2.20, Pc=0.043). The allele frequency of HLA-DRB1*09 was significantly 
      higher in patients with UC diagnosed at the age of 40 years or older than in 
      those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022). Besides 
      these positive associations, no significant differences were found in the allele 
      frequencies between the other subgroups. We conclude that HLA-DRB1*09 is 
      associated with the age at diagnosis and HLA-DRB1*08 is associated with the 
      disease extent of UC in Japanese. These results indicate that HLA-DRB1 is not 
      only associated with the overall UC susceptibility but also associated with the 
      clinical phenotypes in Japanese.
FAU - Matsumura, Y
AU  - Matsumura Y
AD  - Division of Gastroenterology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan. matmat@white.plala.or.jp
FAU - Kinouchi, Y
AU  - Kinouchi Y
FAU - Nomura, E
AU  - Nomura E
FAU - Negoro, K
AU  - Negoro K
FAU - Kakuta, Y
AU  - Kakuta Y
FAU - Endo, K
AU  - Endo K
FAU - Aizawa, H
AU  - Aizawa H
FAU - Takagi, S
AU  - Takagi S
FAU - Takahashi, S
AU  - Takahashi S
FAU - Shimosegawa, T
AU  - Shimosegawa T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Colitis, Ulcerative/epidemiology/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
EDAT- 2008/04/18 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/04/18 09:00
PHST- 2008/04/18 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/04/18 09:00 [entrez]
AID - TAN1031 [pii]
AID - 10.1111/j.1399-0039.2008.01031.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 May;71(5):447-52. doi: 10.1111/j.1399-0039.2008.01031.x.