PMID- 18419057
OWN - NLM
STAT- MEDLINE
DCOM- 20080506
LR  - 20081216
IS  - 2072-0939 (Print)
IS  - 2072-0939 (Linking)
VI  - 31
IP  - 1
DP  - 2008 Jan-Feb
TI  - Implantable cardioverter defibrillator therapy: ten years experience in a medical 
      center.
PG  - 81-90
AB  - BACKGROUND: An implantable cardioverter defibrillator (ICD) is the therapy of 
      choice for survivors of life-threatening ventricular tachyarrhythmias or sudden 
      cardiac death. To date there is little data concerning the clinical features and 
      outcome of ICD therapy among Taiwanese. This study identifies factors related to 
      the outcome of ICD therapy over a ten-year period at this institution. METHODS: 
      Forty-nine ICDs were implanted in 46 patients between August 1996 and January 
      2006. The mean follow-up duration was 32 +/- 21 months. Patient data, primary 
      cardiac diagnosis, presenting cardiac arrhythmia, echocardiographic parameters, 
      hemodynamic indexes, electrophysiologic findings, and follow-up observations were 
      analyzed. The findings were compared to those of the Taiwan ICD Multicenter 
      Registry (TIMR) Study and major secondary prevention ICD trials in the 
      literature. RESULTS: The patients in this study were comparable to those of TIMR 
      but were younger and had better left ventricular ejection fractions (LVEF) than 
      those in Western countries. Furthermore, higher mortality on follow-up was 
      observed in patients with any of the following: LVEF < 35%, New York Heart 
      Association (NYHA) functional class III or IV, a left atrial dimension > or = 55 
      mm, a left ventricular end diastolic dimension > or = 75 mm, an end systolic 
      dimension > or = 60 mm, triple vessel disease, a prior anterior myocardial 
      infarction, and amiodarone or diuretic therapy. Patients with structural heart 
      disease other than ischemic heart disease or dilated cardiomyopathy had higher 
      event recurrence rates. CONCLUSION: Left ventricular function is a major 
      determinant affecting the outcome in ICD recipients. Aggressive treatment for 
      heart failure is warranted in these patients.
FAU - Chen, Tien-En
AU  - Chen TE
AD  - Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung 
      University College of Medicine, Gueishan Township, Taoyuan, Taiwan, ROC.
FAU - Wang, Chun-Chieh
AU  - Wang CC
FAU - Chang, Shang-Hung
AU  - Chang SH
FAU - Yeh, San-Jou
AU  - Yeh SJ
FAU - Wu, Delon
AU  - Wu D
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Chang Gung Med J
JT  - Chang Gung medical journal
JID - 101088034
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Defibrillators, Implantable
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tachycardia, Ventricular/mortality/physiopathology/*therapy
MH  - Ventricular Fibrillation/mortality/physiopathology/*therapy
MH  - Ventricular Function, Left
EDAT- 2008/04/19 09:00
MHDA- 2008/05/07 09:00
CRDT- 2008/04/19 09:00
PHST- 2008/04/19 09:00 [pubmed]
PHST- 2008/05/07 09:00 [medline]
PHST- 2008/04/19 09:00 [entrez]
AID - 3101/310109 [pii]
PST - ppublish
SO  - Chang Gung Med J. 2008 Jan-Feb;31(1):81-90.