PMID- 18420114
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20220318
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 42
IP  - 3
DP  - 2008 May
TI  - Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all 
      three-trimester equivalent repeated binge alcohol exposure: ovine model.
PG  - 199-205
LID - 10.1016/j.alcohol.2007.12.004 [doi]
AB  - Alcohol-mediated alterations in hypothalamic-pituitary-adrenal (HPA) and 
      hypothalamic-pituitary-thyroid axis function are two proposed mechanisms by which 
      alcohol causes neurodevelopmental injury to the fetus. We previously reported 
      that third-trimester equivalent only alcohol exposure in sheep results in 
      increases in the maternal and fetal adrenocorticotropin and cortisol levels, and 
      decreases in the fetal thyroid hormones T(3) and T(4) and maternal T(3) levels. 
      In this study, we wished to characterize the maternal HPA and 
      hypothalamic-pituitary-thyroid hormone responses to repeated binge alcohol 
      exposure during all three-trimester equivalents of pregnancy in sheep. Pregnant 
      ewes received intravenous infusions of alcohol at doses of 0.75, 1.25, or 1.75 
      g/kg over 1h with mean peak blood alcohol concentrations of 90, 126, or 183 
      mg/dl, respectively, on 3 consecutive days each week beginning on gestational day 
      (GD) 4. Maternal blood samples were collected on GDs 6, 40, 90, and 132. Maternal 
      plasma concentrations of adrenocorticotropin and cortisol increased in response 
      to the high alcohol dose, and the magnitude of these elevations was not different 
      across gestation. Thyroid hormone levels were not different when comparing among 
      treatment groups at any time point during gestation. However, there was an 
      ontogenetic decrease in the maternal T(3) concentration beginning between GDs 6 
      and 40 and a decrease in maternal T(4) and free T(4) beginning between GDs 40 and 
      90. The current findings suggest that (1) maternal alcohol consumption at any 
      time during gestation stimulates the HPA axis, (2) maternal HPA responsiveness to 
      alcohol does not change across gestation, (3) binge alcohol exposure at these 
      doses lasting all three-trimester equivalent of human brain development does not 
      reduce maternal thyroid hormone concentration, (4) alterations in fetal thyroid 
      function in response to alcohol exposure do not occur as a result of diminished 
      maternal thyroid hormone contribution, and (5) there is an ontogenetic decrease 
      in ovine maternal thyroid hormones over gestation.
FAU - Ramadoss, Jayanth
AU  - Ramadoss J
AD  - Department of Veterinary Physiology and Pharmacology and Michael E. DeBakey 
      Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A&M 
      University, College Station, TX 77843, USA.
FAU - Tress, Ursula
AU  - Tress U
FAU - Chen, Wei-Jung A
AU  - Chen WJ
FAU - Cudd, Timothy A
AU  - Cudd TA
LA  - eng
GR  - R01 AA010940/AA/NIAAA NIH HHS/United States
GR  - R01 AA010940-09/AA/NIAAA NIH HHS/United States
GR  - AA 10940/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 3K9958V90M (Ethanol)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - Q51BO43MG4 (Thyroxine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/*blood
MH  - Alcohol Drinking/*blood
MH  - Animals
MH  - Central Nervous System Depressants/administration & dosage/*pharmacology
MH  - Data Interpretation, Statistical
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/blood/*physiopathology
MH  - Fetal Weight/drug effects
MH  - Fetus/drug effects
MH  - Hydrocortisone/*blood
MH  - Infusions, Intravenous
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Pregnancy, Animal/*drug effects
MH  - Sheep
MH  - Thyroid Function Tests
MH  - Thyroid Hormones/*blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
PMC - PMC2435381
MID - NIHMS49033
EDAT- 2008/04/19 09:00
MHDA- 2008/06/24 09:00
PMCR- 2009/05/01
CRDT- 2008/04/19 09:00
PHST- 2007/09/24 00:00 [received]
PHST- 2007/12/07 00:00 [revised]
PHST- 2007/12/10 00:00 [accepted]
PHST- 2008/04/19 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2008/04/19 09:00 [entrez]
PHST- 2009/05/01 00:00 [pmc-release]
AID - S0741-8329(08)00018-9 [pii]
AID - 10.1016/j.alcohol.2007.12.004 [doi]
PST - ppublish
SO  - Alcohol. 2008 May;42(3):199-205. doi: 10.1016/j.alcohol.2007.12.004.