PMID- 18421262
OWN - NLM
STAT- MEDLINE
DCOM- 20080912
LR  - 20211027
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 16
IP  - 7
DP  - 2008 Jul
TI  - Childhood obesity: genetic and environmental overlap with normal-range BMI.
PG  - 1585-90
LID - 10.1038/oby.2008.240 [doi]
AB  - OBJECTIVE: To understand the overlap between the etiology of obesity and normal 
      variation in BMI in children. METHODS AND PROCEDURES: Height and weight data were 
      available from a large UK representative sample of twins: 2,342 same-sex pairs at 
      7 years and 3,526 same-sex pairs at 10 years. The twin method and model-fitting 
      techniques were used to estimate genetic and environmental contributions to BMI. 
      DeFries-Fulker (DF) extremes analysis was used to investigate genetic and 
      environmental influences on the mean difference between obese and normal-weight 
      children. Obesity was classified using the International Obesity Task Force 
      (IOTF) criteria. RESULTS: At both ages, BMI and obesity were highly heritable 
      (0.60-0.74) and only modestly influenced by shared environmental factors 
      (0.12-0.22). Extremes analyses indicated that genetic and environmental 
      influences on obesity are quantitatively and qualitatively similar to those 
      operating across the range of BMI. DISCUSSION: Obesity is the extreme of the same 
      genetic and environmental factors responsible for variation throughout the 
      distribution of BMI. This finding implies that genes that influence obesity will 
      also be associated with BMI in the normal range, and similar environmental 
      influences will affect BMI in the clinical and normal range. Knowing that obesity 
      is influenced by the same genetic and environmental factors that affect weight at 
      all levels has implications for investigating the mechanisms for weight gain and 
      developing interventions for weight control.
FAU - Haworth, Claire M A
AU  - Haworth CM
AD  - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, 
      King's College London, London, UK. Claire.Haworth@iop.kcl.ac.uk
FAU - Plomin, Robert
AU  - Plomin R
FAU - Carnell, Susan
AU  - Carnell S
FAU - Wardle, Jane
AU  - Wardle J
LA  - eng
GR  - G0500079/MRC_/Medical Research Council/United Kingdom
GR  - G0500079(73692)/MRC_/Medical Research Council/United Kingdom
GR  - G19/2/MRC_/Medical Research Council/United Kingdom
GR  - 31/D19086/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Twin Study
DEP - 20080417
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - *Body Mass Index
MH  - Child
MH  - *Environment
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Models, Genetic
MH  - Obesity/*genetics
MH  - Reference Values
MH  - Risk Factors
MH  - Twins, Dizygotic/genetics
MH  - Twins, Monozygotic/genetics
MH  - United Kingdom
MH  - Weight Gain/*genetics
EDAT- 2008/04/19 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/04/19 09:00
PHST- 2008/04/19 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/04/19 09:00 [entrez]
AID - oby2008240 [pii]
AID - 10.1038/oby.2008.240 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2008 Jul;16(7):1585-90. doi: 10.1038/oby.2008.240. Epub 
      2008 Apr 17.