PMID- 18421425 OWN - NLM STAT- MEDLINE DCOM- 20080828 LR - 20211020 IS - 0885-7490 (Print) IS - 0885-7490 (Linking) VI - 23 IP - 2 DP - 2008 Jun TI - Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector. PG - 199-211 LID - 10.1007/s11011-008-9084-7 [doi] AB - We investigated the age-related alterations in nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), parvalbumin and neuronal nitric oxide synthase (nNOS) immunoreactivity of the mouse hippocampal CA1 sector. NGF and BDNF immunoreactivity was unchanged in the hippocampal CA1 pyramidal neurons from 2 to 50-59 weeks of birth. In contrast, a significant increase in the NGF and BDNF immunoreactivity was observed in glial cells of the hippocampal CA1 sector from 40-42 to 50-59 weeks of birth. On the other hand, the number of parvalbumin- and nNOS-positive interneurons was unchanged in the hippocampal CA1 sector during aging processes, except for a significant decrease of nNOS-positive interneurons 2 weeks of birth. Our results indicate that NGF and BDNF immunoreactivity was unaltered in the hippocampal CA1 pyramidal neurons during aging processes. In contrast, a significant increase in the NGF and BDNF immunoreactivity was observed in glial cells of the hippocampal CA1 sector during aging processes. The present study also shows that the number of parvalbumin- and nNOS-positive interneurons was unchanged in the hippocampal CA1 sector during aging processes, except for a significant decrease of nNOS-positive interneurons 2 weeks of birth. These results demonstrate that the expression of glial NGF and BDNF may play a key role for helping survival and maintenance of pyramidal neurons and neuronal functions in the hippocampal CA1 sector during aging processes. Furthermore, our findings suggest that parvalbumin- and nNOS-positive interneurons in the hippocampal CA1 sector are resistant to aging processes. Moreover, our findings suggest that nitric oxide synthesized by the nNOS may play some role for neuronal growth during postnatal development. FAU - Hayakawa, Natsumi AU - Hayakawa N AD - Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, Tokushima, 770-8505, Japan. FAU - Abe, Manami AU - Abe M FAU - Eto, Risa AU - Eto R FAU - Kato, Hiroyuki AU - Kato H FAU - Araki, Tsutomu AU - Araki T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080418 PL - United States TA - Metab Brain Dis JT - Metabolic brain disease JID - 8610370 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Parvalbumins) RN - 31C4KY9ESH (Nitric Oxide) RN - 9061-61-4 (Nerve Growth Factor) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type I) SB - IM MH - Aging/*metabolism MH - Animals MH - Brain-Derived Neurotrophic Factor/metabolism MH - Cell Count MH - Cell Proliferation MH - Cell Survival/physiology MH - Hippocampus/cytology/*metabolism MH - Immunohistochemistry MH - Interneurons/enzymology MH - Male MH - Mice MH - Mice, Inbred ICR MH - Nerve Growth Factor/metabolism MH - Nerve Growth Factors/*metabolism MH - Neuroglia/metabolism MH - Neurons/*metabolism MH - Nitric Oxide/biosynthesis MH - Nitric Oxide Synthase Type I/*metabolism MH - Parvalbumins/*metabolism MH - Pyramidal Cells/enzymology EDAT- 2008/04/19 09:00 MHDA- 2008/08/30 09:00 CRDT- 2008/04/19 09:00 PHST- 2008/01/29 00:00 [received] PHST- 2008/03/06 00:00 [accepted] PHST- 2008/04/19 09:00 [pubmed] PHST- 2008/08/30 09:00 [medline] PHST- 2008/04/19 09:00 [entrez] AID - 10.1007/s11011-008-9084-7 [doi] PST - ppublish SO - Metab Brain Dis. 2008 Jun;23(2):199-211. doi: 10.1007/s11011-008-9084-7. Epub 2008 Apr 18.