PMID- 18423564
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20220317
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 122
IP  - 1
DP  - 2008 Jul
TI  - Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune 
      responses.
PG  - 195-201, 201.e1-5
LID - 10.1016/j.jaci.2008.03.012 [doi]
AB  - BACKGROUND: The transcription factor Yin-Yang 1 (YY-1) binds to the promoter 
      regions of several T-cell cytokine genes, but the expression and contribution of 
      this factor to cytokine gene expression and T-cell activation in vivo is not 
      clear. OBJECTIVE: We sought to better define the role of YY-1 in T-cell gene 
      regulation and allergic immune responses. METHODS: We studied cytokine gene 
      expression in T lymphocytes isolated from wild-type mice and heterozygous 
      littermates bearing 1 targeted yy-1 allele (yy-1(+/-) mice). T cells were 
      stimulated with anti-T-cell receptor (anti-TCR) plus CD28 antibodies or with 
      peptide antigen plus antigen-presenting cells by using newly generated yy-1(+/-) 
      TCR transgenic mice. We also studied ovalbumin-driven allergic immune responses 
      in a mouse model of asthma and YY-1 expression in lung tissue from human 
      asthmatic subjects. RESULTS: CD4(+) T cells from yy-1(+/-) mice secreted 
      significantly less IL-4 and IFN-gamma compared with wild-type littermates after 
      TCR-dependent activation, whereas IL-2 production was not significantly affected. 
      Both airway inflammation and recall splenocyte IL-4 production were inhibited in 
      yy-1(+/-) mice, as was antigen-driven T-cell proliferation. YY-1 expression was 
      higher in airway biopsy specimens from asthmatic compared with control subjects. 
      CONCLUSION: These data indicate that YY-1 regulates T-cell cytokine gene 
      expression and allergic immune responses in a gene dose-dependent manner.
FAU - Guo, Jia
AU  - Guo J
AD  - Division of Pulmonary and Critical Care Medicine, University of Rochester Medical 
      Center, Rochester, NY, USA.
FAU - Lin, Xin
AU  - Lin X
FAU - Williams, Marc A
AU  - Williams MA
FAU - Hamid, Qutayba
AU  - Hamid Q
FAU - Georas, Steve N
AU  - Georas SN
LA  - eng
GR  - R01 HL073952/HL/NHLBI NIH HHS/United States
GR  - R01HL073952/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080418
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (YY1 Transcription Factor)
RN  - 0 (Yy1 protein, mouse)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology/metabolism
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - Cell Proliferation
MH  - Gene Expression
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Interferon-gamma/*genetics/immunology/metabolism
MH  - Interleukin-4/*genetics/immunology/metabolism
MH  - Lung/immunology/metabolism
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Transgenic
MH  - Ovalbumin/immunology
MH  - Th2 Cells/*immunology/metabolism
MH  - YY1 Transcription Factor/deficiency/genetics/*metabolism
PMC - PMC7065358
MID - NIHMS1567026
COIS- Disclosure of potential conflict of interest: The authors have declared that they 
      have no conflict of interest.
EDAT- 2008/04/22 09:00
MHDA- 2008/07/30 09:00
PMCR- 2020/03/11
CRDT- 2008/04/22 09:00
PHST- 2007/10/23 00:00 [received]
PHST- 2008/03/06 00:00 [revised]
PHST- 2008/03/10 00:00 [accepted]
PHST- 2008/04/22 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/04/22 09:00 [entrez]
PHST- 2020/03/11 00:00 [pmc-release]
AID - S0091-6749(08)00595-2 [pii]
AID - 10.1016/j.jaci.2008.03.012 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2008 Jul;122(1):195-201, 201.e1-5. doi: 
      10.1016/j.jaci.2008.03.012. Epub 2008 Apr 18.