PMID- 18423578
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20230113
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1210
DP  - 2008 May 19
TI  - Hippocampal neurogenesis and gene expression depend on exercise intensity in 
      juvenile rats.
PG  - 48-55
LID - 10.1016/j.brainres.2008.02.080 [doi]
AB  - Exercise can increase neurogenesis and affect gene expression in the brains of 
      adult rats. Little is known about how exercise intensity affects neurogenesis and 
      associated gene expression in juvenile rats. Here, we show that exercise 
      influenced neurogenesis and mRNA expression of brain derived neurotrophic factor 
      (BDNF), N-methyl-d-aspartate receptor type 1 (NMDAR1), vascular endothelial 
      growth factor (VEGF) and fetal liver kinase-1 (Flk-1) in the hippocampus of 5 
      weeks old rats in an intensity-dependent manner. One week of low- or 
      moderate-intensity exercise in a treadmill running task enhanced neurogenesis in 
      the dentate gyrus of hippocampus. The low-, but not the high-, intensity exercise 
      paradigm resulted in significantly increased expression of BDNF, NMDAR1, and 
      Flk-1 mRNA. Gene expression levels in the low-intensity exercise group were 
      greater than the high-intensity group for these four molecules.
FAU - Lou, Shu-jie
AU  - Lou SJ
AD  - Center of Exercise Molecular Biology, Department of Exercise and Sport Science, 
      Shanghai University of Sport, 200 Hengren Road, Shanghai, 200438, China. 
      shujielou319@yahoo.com.cn
FAU - Liu, Jin-yan
AU  - Liu JY
FAU - Chang, Hui
AU  - Chang H
FAU - Chen, Pei-jie
AU  - Chen PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080307
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Bromodeoxyuridine
MH  - Cell Count
MH  - Cell Differentiation/genetics
MH  - *Cell Proliferation
MH  - Exercise Test
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Hippocampus/cytology/*growth & development/metabolism
MH  - Male
MH  - Neuronal Plasticity/*genetics
MH  - Neurons/cytology/metabolism
MH  - Physical Conditioning, Animal/*physiology
MH  - *Physical Exertion
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/genetics
MH  - Stem Cells/cytology/metabolism
MH  - Up-Regulation/genetics
MH  - Vascular Endothelial Growth Factor A/genetics
MH  - Vascular Endothelial Growth Factor Receptor-2/genetics
EDAT- 2008/04/22 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/04/22 09:00
PHST- 2007/07/19 00:00 [received]
PHST- 2008/02/16 00:00 [revised]
PHST- 2008/02/25 00:00 [accepted]
PHST- 2008/04/22 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/22 09:00 [entrez]
AID - S0006-8993(08)00522-2 [pii]
AID - 10.1016/j.brainres.2008.02.080 [doi]
PST - ppublish
SO  - Brain Res. 2008 May 19;1210:48-55. doi: 10.1016/j.brainres.2008.02.080. Epub 2008 
      Mar 7.