PMID- 18424195
OWN - NLM
STAT- MEDLINE
DCOM- 20080805
LR  - 20211020
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 867
IP  - 2
DP  - 2008 May 15
TI  - Development and validation of a liquid chromatography-atmospheric pressure 
      chemical ionization-tandem mass spectrometry method for simultaneous analysis of 
      10 amphetamine-, methamphetamine- and 3,4-methylenedioxymethamphetamine-related 
      (MDMA) analytes in human meconium.
PG  - 194-204
LID - 10.1016/j.jchromb.2008.03.029 [doi]
AB  - A liquid chromatography-atmospheric pressure chemical ionization-tandem mass 
      spectrometry (LC-APCI-MS/MS) method for quantification of 10 amphetamine-related 
      analytes in 1g meconium is presented. Specimen preparation included 
      homogenization and solid-phase extraction. Two multiple reaction monitoring 
      transitions were monitored per analyte. Ten and 1 microL injection volumes 
      permitted quantification up to 10,000 ng/g, with sufficient sensitivity to 
      quantify minor metabolites. Lower limits of quantification ranged from 1.25 to 40 
      ng/g. Precision was less than 14.2%, with accuracy between 79 and 115%. Meconium 
      from a methamphetamine-exposed neonate was analyzed. Metabolites 
      p-hydroxymethamphetamine, norephedrine and 4-hydroxy-3-methoxymethamphetamine 
      were identified in meconium for the first time.
FAU - Kelly, Tamsin
AU  - Kelly T
AD  - Chemistry and Drug Metabolism, Clinical Pharmacology and Therapeutics Research 
      Branch, Intramural Research Program, National Institute on Drug Abuse, National 
      Institutes of Health, 251 Bayview Blvd., Suite 05A721, Baltimore, MD 21224, USA.
FAU - Gray, Teresa R
AU  - Gray TR
FAU - Huestis, Marilyn A
AU  - Huestis MA
LA  - eng
GR  - NIH0012986137/ImNIH/Intramural NIH HHS/United States
GR  - Z01 DA000433-08/ImNIH/Intramural NIH HHS/United States
GR  - Z01 DA000468-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Validation Study
DEP - 20080404
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Amphetamines)
SB  - IM
MH  - Amphetamines/*analysis
MH  - Atmospheric Pressure
MH  - Calibration
MH  - Chromatography, Liquid/*methods
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Meconium/*chemistry
MH  - Reference Standards
MH  - Tandem Mass Spectrometry/*methods
PMC - PMC2587330
MID - NIHMS52886
EDAT- 2008/04/22 09:00
MHDA- 2008/08/06 09:00
PMCR- 2009/05/15
CRDT- 2008/04/22 09:00
PHST- 2007/12/20 00:00 [received]
PHST- 2008/03/24 00:00 [revised]
PHST- 2008/03/30 00:00 [accepted]
PHST- 2008/04/22 09:00 [pubmed]
PHST- 2008/08/06 09:00 [medline]
PHST- 2008/04/22 09:00 [entrez]
PHST- 2009/05/15 00:00 [pmc-release]
AID - S1570-0232(08)00203-1 [pii]
AID - 10.1016/j.jchromb.2008.03.029 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):194-204. doi: 
      10.1016/j.jchromb.2008.03.029. Epub 2008 Apr 4.