PMID- 18426829
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20161124
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 158
IP  - 5
DP  - 2008 May
TI  - Natural course of small adrenal lesions in multiple endocrine neoplasia type 1: 
      an endoscopic ultrasound imaging study.
PG  - 699-704
LID - 10.1530/EJE-07-0635 [doi]
AB  - OBJECTIVE: Adrenal lesion is one of the features of multiple endocrine neoplasia 
      type 1 (MEN1). This study aimed to assess prevalence, natural course and clinical 
      relevance of small adrenal lesions without clinical symptoms, endocrine activity, 
      or mechanical problems and thus without clear indication for surgical therapy by 
      endoscopic ultrasound (EUS). DESIGN AND METHODS: Forty-nine patients with 
      familial MEN1 were studied. Twenty-seven of these with adrenal lesions were 
      detected by EUS and at least two performed EUS examinations were included into a 
      subgroup where changes in adrenal morphology were studied by measuring changes in 
      the largest diameter of the dominant adrenal tumour. RESULTS: EUS detected 
      adrenal lesions in 36 (73%) patients: 6 (12%) plump adrenals, 17 (35%) nodular 
      hyperplasia, 12 (24%) adenomas and 1 (2%) cyst. Bilateral adrenal lesions were 
      detected in 17 patients and unilateral in 19 patients. A change in the largest 
      tumour diameter was found to be for nodular hyperplasia -0.02+/-1.41% per month 
      (range -2.56 to 4.58%) and for adenomas -0.61+/-1.95% per month (range -6.25 to 
      1.15%). One patient had an adrenal cyst with significant growth. There was no 
      evidence of carcinoma or metastatic disease during the study. CONCLUSIONS: The 
      prevalence of adrenal lesions in MEN1 is higher than that reported earlier. 
      Except one cystic lesion, no significant change in the tumour size was observed 
      over a mean observation period of more than 2 years. In a typical situation, 
      small adrenal lesions in MEN1 seem to be constant in their morphology.
FAU - Schaefer, S
AU  - Schaefer S
AD  - Division of Endocrinology and Diabetology, Philipp's University, D-35033 Marburg, 
      Germany (EU).
FAU - Shipotko, M
AU  - Shipotko M
FAU - Meyer, S
AU  - Meyer S
FAU - Ivan, D
AU  - Ivan D
FAU - Klose, K J
AU  - Klose KJ
FAU - Waldmann, J
AU  - Waldmann J
FAU - Langer, P
AU  - Langer P
FAU - Kann, P H
AU  - Kann PH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
SB  - IM
MH  - Adenoma/*diagnostic imaging/*epidemiology
MH  - Adrenal Gland Neoplasms/*diagnostic imaging/*epidemiology
MH  - Adrenal Glands/diagnostic imaging
MH  - Adult
MH  - Cushing Syndrome/diagnostic imaging/epidemiology
MH  - Endosonography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging/*epidemiology
MH  - Prevalence
EDAT- 2008/04/23 09:00
MHDA- 2008/05/16 09:00
CRDT- 2008/04/23 09:00
PHST- 2008/04/23 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2008/04/23 09:00 [entrez]
AID - 158/5/699 [pii]
AID - 10.1530/EJE-07-0635 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2008 May;158(5):699-704. doi: 10.1530/EJE-07-0635.