PMID- 18426850
OWN - NLM
STAT- MEDLINE
DCOM- 20081224
LR  - 20220408
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 29
IP  - 15
DP  - 2008 Aug
TI  - Running: the risk of coronary events : Prevalence and prognostic relevance of 
      coronary atherosclerosis in marathon runners.
PG  - 1903-10
LID - 10.1093/eurheartj/ehn163 [doi]
AB  - AIMS: To quantify the prevalence of coronary artery calcification (CAC) in 
      relation to cardiovascular risk factors in marathon runners, and to study its 
      role for myocardial damage and coronary events. METHODS AND RESULTS: In 108 
      apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon 
      competitions during the previous three years, the running history, Framingham 
      risk score (FRS), CAC, and presence of myocardial late gadolinium enhancement 
      (LGE) were measured. Control groups were matched by age (8:1) and FRS (2:1) from 
      the Heinz Nixdorf Recall Study. The FRS in marathon runners was lower than in 
      age-matched controls (7 vs. 11%, P < 0.0001). However, the CAC distribution was 
      similar in marathon runners and age-matched controls (median CAC: 36 vs. 38, P = 
      0.36) and higher in marathon runners than in FRS-matched controls (median CAC: 36 
      vs. 12, P = 0.02). CAC percentile values and number of marathons independently 
      predicted the presence of LGE (prevalence = 12%) (P = 0.02 for both). During 
      follow-up after 21.3 +/- 2.8 months, four runners with CAC >or= 100 experienced 
      coronary events. Event-free survival was inversely related to CAC burden (P = 
      0.018). CONCLUSION: Conventional cardiovascular risk stratification 
      underestimates the CAC burden in presumably healthy marathon runners. As CAC 
      burden and frequent marathon running seem to correlate with subclinical 
      myocardial damage, an increased awareness of a potentially higher than 
      anticipated coronary risk is warranted.
FAU - Mohlenkamp, Stefan
AU  - Mohlenkamp S
AD  - Clinic of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, 
      Hufelandstrasse 55, 45122 Essen, Germany. stefan.moehlenkamp@uk-essen.de
FAU - Lehmann, Nils
AU  - Lehmann N
FAU - Breuckmann, Frank
AU  - Breuckmann F
FAU - Brocker-Preuss, Martina
AU  - Brocker-Preuss M
FAU - Nassenstein, Kai
AU  - Nassenstein K
FAU - Halle, Martin
AU  - Halle M
FAU - Budde, Thomas
AU  - Budde T
FAU - Mann, Klaus
AU  - Mann K
FAU - Barkhausen, Jorg
AU  - Barkhausen J
FAU - Heusch, Gerd
AU  - Heusch G
FAU - Jockel, Karl-Heinz
AU  - Jockel KH
FAU - Erbel, Raimund
AU  - Erbel R
CN  - Marathon Study Investigators
CN  - Heinz Nixdorf Recall Study Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080421
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
CIN - Eur Heart J. 2008 Aug;29(15):1800-2. PMID: 18556710
MH  - Aged
MH  - Calcinosis/diagnosis/*physiopathology
MH  - Coronary Artery Disease/diagnosis/*physiopathology
MH  - Death, Sudden, Cardiac/prevention & control
MH  - Diabetic Angiopathies/complications
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physical Endurance
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Running/*physiology
MH  - Tomography, X-Ray Computed
EDAT- 2008/04/23 09:00
MHDA- 2008/12/25 09:00
CRDT- 2008/04/23 09:00
PHST- 2008/04/23 09:00 [pubmed]
PHST- 2008/12/25 09:00 [medline]
PHST- 2008/04/23 09:00 [entrez]
AID - ehn163 [pii]
AID - 10.1093/eurheartj/ehn163 [doi]
PST - ppublish
SO  - Eur Heart J. 2008 Aug;29(15):1903-10. doi: 10.1093/eurheartj/ehn163. Epub 2008 
      Apr 21.