PMID- 18430312
OWN - NLM
STAT- MEDLINE
DCOM- 20080814
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 29
IP  - 2
DP  - 2008 Mar-Apr
TI  - Correlation between specific IgA and eosinophil numbers in the lavage fluid of 
      patients with perennial allergic rhinitis.
PG  - 152-60
LID - 10.2500/aap.2008.29.3069 [doi]
AB  - The mechanisms of eosinophil activation in perennial allergic rhinitis (AR) are 
      not fully understood but may be mediated by a series of inflammatory mediators, 
      including locally produced specific antibodies. The aim of this study was to 
      evaluate the role of locally produced allergen-specific antibodies in the nasal 
      lavage fluid during the recruitment of inflammatory cells in AR. Thirteen 
      patients with AR and a positive nasal provocation test (NPT) with 
      Dermatophagoides pteronyssinus and 10 asymptomatic subjects, sensitized to D. 
      pteronyssinus but who had a negative NPT were enrolled. Nasal lavage fluids were 
      collected before and at 10, 30, and 60 minutes and 3, 6, and 24 hours after the 
      NPT. Inflammatory cells were counted, and eosinophil cationic protein (ECP) and 
      specific immunoglobulin E (IgE), IgG, and IgA antibodies were measured by 
      enzyme-linked immunosorbent assay. After NPT, six subjects showed early responses 
      and seven subjects showed dual responses. The eosinophil count and ECP level in 
      lavage fluid were significantly increased after NPT in patients with positive 
      NPTs, and these values were significantly higher than in the negative group. The 
      specific IgA level in lavage fluid was increased after NPT in the positive group, 
      and significant differences were noted for both the early and the late positive 
      responses. Significant correlations were found between specific IgA and ECP 
      levels in lavage fluid during early and late responses. Eosinophil recruitment 
      occurred during both early and late responses after allergen exposure in 
      perennial AR. Locally produced allergen-specific IgA (but not IgE or IgG) may be 
      involved in eosinophil activation in both early and late responses.
FAU - Oh, Jeong-Hoon
AU  - Oh JH
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Hur, Gyu-Young
AU  - Hur GY
FAU - Ye, Young-Min
AU  - Ye YM
FAU - Kim, Jeong Eun
AU  - Kim JE
FAU - Park, Keehyun
AU  - Park K
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Antigens, Dermatophagoides/*immunology
MH  - Eosinophils/*immunology/metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/*analysis
MH  - Immunoglobulin E/analysis
MH  - Immunoglobulin G/analysis
MH  - Leukocyte Count
MH  - Male
MH  - Nasal Lavage Fluid/*immunology
MH  - Nasal Provocation Tests
MH  - Rhinitis, Allergic, Perennial/*immunology/metabolism
EDAT- 2008/04/24 09:00
MHDA- 2008/08/15 09:00
CRDT- 2008/04/24 09:00
PHST- 2008/04/24 09:00 [pubmed]
PHST- 2008/08/15 09:00 [medline]
PHST- 2008/04/24 09:00 [entrez]
AID - 10.2500/aap.2008.29.3069 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2008 Mar-Apr;29(2):152-60. doi: 10.2500/aap.2008.29.3069.