PMID- 18430535
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20080526
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 43
IP  - 6
DP  - 2008 Jun
TI  - Pituitary growth hormone suppression reduces resistin expression and enhances 
      insulin effectiveness: relationship with caloric restriction.
PG  - 595-600
LID - 10.1016/j.exger.2008.03.003 [doi]
AB  - Caloric restriction (CR) retards various age-dependent disorders, increases 
      lifespan, and improves insulin activity in laboratory animals. Recently, 
      adipocytes were found to act together as an active endocrine organ that produces 
      various hormones called adipocytokines. The peripheral and central activities of 
      these adipocytokines have been suggested to mediate the anti-aging effects of CR. 
      Here, we tested this notion by analyzing the effect of CR and suppression of 
      growth hormone/insulin-like growth factor-I (GH/IGF-I) axis on the expression of 
      resistin, adiponectin, and adipsin genes by rat white adipose tissue (WAT). We 
      found that CR and GH/IGF-I suppression markedly downregulated resistin gene 
      expression. We also found plasma resistin levels correlated positively with 
      pituitary GH mRNA expression levels. Our observations suggest that CR reduces 
      resistin expression and increases insulin effectiveness in a GH/IGF-I-dependent 
      manner. The beneficial effects of CR and GH/IGF-I suppression appear to be 
      mediated, at least in part, by changes in glucose metabolism that result from 
      reductions in plasma resistin levels.
FAU - Chiba, Takuya
AU  - Chiba T
AD  - Department of Investigative Pathology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Nagasaki 852-8523, Japan. 
      takuya@net.nagsaki-u.ac.jp
FAU - Yamaza, Haruyoshi
AU  - Yamaza H
FAU - Komatsu, Toshimitsu
AU  - Komatsu T
FAU - Nakayama, Masahiko
AU  - Nakayama M
FAU - Fujita, Satoshi
AU  - Fujita S
FAU - Hayashi, Hiroko
AU  - Hayashi H
FAU - Higami, Yoshikazu
AU  - Higami Y
FAU - Shimokawa, Isao
AU  - Shimokawa I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080320
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Adiponectin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Resistin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - EC 3.4.21.46 (Complement Factor D)
SB  - IM
MH  - Adiponectin/genetics/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Blotting, Northern/methods
MH  - *Caloric Restriction
MH  - Complement Factor D/genetics/metabolism
MH  - Diet
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Growth Hormone/genetics/*physiology
MH  - *Insulin Resistance
MH  - Insulin-Like Growth Factor I/genetics/metabolism
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Resistin/blood/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
EDAT- 2008/04/24 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/04/24 09:00
PHST- 2008/01/03 00:00 [received]
PHST- 2008/02/28 00:00 [revised]
PHST- 2008/03/11 00:00 [accepted]
PHST- 2008/04/24 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/04/24 09:00 [entrez]
AID - S0531-5565(08)00087-9 [pii]
AID - 10.1016/j.exger.2008.03.003 [doi]
PST - ppublish
SO  - Exp Gerontol. 2008 Jun;43(6):595-600. doi: 10.1016/j.exger.2008.03.003. Epub 2008 
      Mar 20.