PMID- 18430790
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20161124
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 159
IP  - 1
DP  - 2008 Jul
TI  - Insulinoma cell calcium-sensing receptor influences insulin secretion in a case 
      with concurrent familial hypocalciuric hypercalcemia and malignant metastatic 
      insulinoma.
PG  - 81-6
LID - 10.1530/EJE-08-0069 [doi]
AB  - CONTEXT AND OBJECTIVE: Arterial stimulation and venous sampling (ASVS) is an 
      important technique for localizing insulinoma. The principle behind ASVS is that 
      insulin secretion is promoted from insulinoma cells by the injection of calcium 
      into the insulinoma-feeding artery. However, the mechanism for ASVS-induced 
      insulin secretion remains unclear. Both insulinoma and familial hypocalciuric 
      hypercalcemia (FHH) are rare diseases. This study reports on a case in which both 
      of these diseases occur concurrently. DESIGN AND PATIENT: The patient with FHH 
      also suffered from insulinoma. We reasoned that insulin secretion for ASVS is 
      dependent on the calcium-sensing receptor (CaSR). ASVS was performed on this 
      patient. The expression of the CaSR protein and corresponding mRNA were 
      confirmed. RESULTS: No significant changes in the plasma levels of insulin and 
      C-peptide were observed during ASVS. The patient was clinically diagnosed as 
      having FHH. We confirmed that a mutation in the CaSR gene was present in the 
      genomic DNA of this patient and that there were no mutations in the multiple 
      endocrine neoplasia type 1 gene. In addition, expression of both CaSR mRNA and 
      CaSR protein was confirmed in the insulinoma samples. CONCLUSION: These results 
      suggest that the CaSR gene is involved in ASVS-induced insulin secretion.
FAU - Ono, Yasunaga
AU  - Ono Y
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita 
      Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
FAU - Oda, Naohisa
AU  - Oda N
FAU - Ishihara, Shin
AU  - Ishihara S
FAU - Shimomura, Atsushi
AU  - Shimomura A
FAU - Hayakawa, Nobuki
AU  - Hayakawa N
FAU - Suzuki, Atsushi
AU  - Suzuki A
FAU - Horiguchi, Akihiko
AU  - Horiguchi A
FAU - Senda, Takao
AU  - Senda T
FAU - Miyakawa, Shuichi
AU  - Miyakawa S
FAU - Itoh, Mitsuyasu
AU  - Itoh M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080422
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Insulin)
RN  - 0 (Receptors, Calcium-Sensing)
SB  - IM
MH  - Blotting, Western
MH  - Female
MH  - Humans
MH  - Hypercalcemia/diagnostic imaging/genetics/metabolism/*pathology
MH  - Immunohistochemistry
MH  - Insulin/metabolism
MH  - Insulinoma/genetics/metabolism/*pathology
MH  - Liver/diagnostic imaging/metabolism/pathology
MH  - Middle Aged
MH  - Pancreas/diagnostic imaging/metabolism/pathology
MH  - Radionuclide Imaging
MH  - Receptors, Calcium-Sensing/genetics/metabolism/*physiology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tomography, X-Ray Computed
EDAT- 2008/04/24 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/04/24 09:00
PHST- 2008/04/24 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/04/24 09:00 [entrez]
AID - EJE-08-0069 [pii]
AID - 10.1530/EJE-08-0069 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2008 Jul;159(1):81-6. doi: 10.1530/EJE-08-0069. Epub 2008 Apr 
      22.