PMID- 18432062
OWN - NLM
STAT- MEDLINE
DCOM- 20080513
LR  - 20131121
IS  - 0030-6096 (Print)
IS  - 0030-6096 (Linking)
VI  - 53
IP  - 2
DP  - 2007 Dec
TI  - Hippocampal BDNF and TrkB expression in young rats after status epilepticus.
PG  - 63-71
AB  - BACKGROUND: The immature brain is more susceptible to seizures than mature brains 
      but less vulnerable to seizure-induced neuronal loss. We studied age-related 
      susceptibility and vulnerability to kainic acid-induced status epilepticus (KASE) 
      in rats in terms of hippocampal expression of brain-derived neurotrophic factor 
      (BDNF) and tyrosine kinase B receptor (TrkB). METHODS: Immunohistochemical and 
      Western analysis were performed after kainic acid (KA)-induced status epilepticus 
      (SE). RESULTS: KA doses required to induce SE increased from 1.5 mg/kg in 
      1-week-old rats to 10 mg/kg at 4 weeks of older. After SE the older rats showed 
      spontaneous seizures and hippocampal pyramidal neuronal loss-unlike rats under 4 
      weeks old. Hippocampal BDNF protein expression had increased fivefold in 
      1-week-old rats and threefold in 8-week-old rats 1 day after SE, returning to 
      baseline 2 days after SE. TrkB expression showed little effect from KASE at 
      either age. CONCLUSIONS: These results indicated that the critical period as for 
      vulnerability to SE was the age of 4-week-old and older in the rat. Since the 
      response patterns of BDNF and TrkB to SE were similar between neonatal and the 
      adult rats, our study revealed that the observed transient upregulation of BDNF 
      did not contribute to cause epilepsy in neonatal rats.
FAU - Yokoi, Toshiaki
AU  - Yokoi T
AD  - Department of Pediatrics, Osaka City University, Graduate School of Medicine, 
      Japan. toshiaki@med.osaka-cu.ac.jp
FAU - Tokuhara, Daisuke
AU  - Tokuhara D
FAU - Saito, Mika
AU  - Saito M
FAU - Ichiba, Hiroyuki
AU  - Ichiba H
FAU - Yamano, Tsunekazu
AU  - Yamano T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Osaka City Med J
JT  - Osaka city medical journal
JID - 0376413
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Agonists
MH  - Hippocampus/growth & development/*metabolism/pathology
MH  - Kainic Acid
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*metabolism
MH  - Status Epilepticus/chemically induced/*metabolism/pathology
EDAT- 2008/04/25 09:00
MHDA- 2008/05/14 09:00
CRDT- 2008/04/25 09:00
PHST- 2008/04/25 09:00 [pubmed]
PHST- 2008/05/14 09:00 [medline]
PHST- 2008/04/25 09:00 [entrez]
PST - ppublish
SO  - Osaka City Med J. 2007 Dec;53(2):63-71.