PMID- 18433045
OWN - NLM
STAT- MEDLINE
DCOM- 20080612
LR  - 20220317
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 14
IP  - 5
DP  - 2008 May
TI  - Cell-mediated rejection results in allograft loss after liver cell 
      transplantation.
PG  - 688-94
LID - 10.1002/lt.21443 [doi]
AB  - Liver cell transplantation in humans has been impeded by invariable loss of the 
      graft. It is unclear whether graft loss is due to an immune response against 
      donor hepatocytes. Transplantation with ABO-matched liver cells was performed in 
      a patient with Crigler-Najjar type 1. After successful engraftment, there was a 
      gradual loss of graft function. Solid-phase enzyme immunoassay testing and 
      cell-complement cytotoxicity assays detecting preformed antibodies directed 
      toward class I and/or class II human leukocyte antigen (HLA) molecules were 
      negative. In contrast, a striking host alloresponse to either the HLA-B39 or C7 
      antigen was found, suggesting that a vigorous response to a defined mismatched 
      HLA antigen contributed to graft loss in our patient. This study provides 
      evidence that a T-cell-mediated immune mechanism could be responsible for human 
      liver cell transplant graft loss. This finding warrants confirmation in future 
      liver cell transplants in humans.
FAU - Allen, Katrina J
AU  - Allen KJ
AD  - Gut and Liver Research Group, Murdoch Childrens Research Institute, Melbourne, 
      Victoria, Australia. katie.allen@rch.org.au
FAU - Mifsud, Nicole A
AU  - Mifsud NA
FAU - Williamson, Robert
AU  - Williamson R
FAU - Bertolino, Patrick
AU  - Bertolino P
FAU - Hardikar, Winita
AU  - Hardikar W
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B39 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Child
MH  - Crigler-Najjar Syndrome/immunology/*surgery
MH  - Female
MH  - Graft Rejection/*immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-B39 Antigen
MH  - HLA-C Antigens/immunology
MH  - Hepatocytes/immunology/*transplantation
MH  - Humans
MH  - *Immunity, Cellular
MH  - *Liver Transplantation
MH  - Reoperation
MH  - T-Lymphocytes/*immunology
MH  - Time Factors
MH  - Transplantation, Homologous
MH  - Treatment Failure
EDAT- 2008/04/25 09:00
MHDA- 2008/06/13 09:00
CRDT- 2008/04/25 09:00
PHST- 2008/04/25 09:00 [pubmed]
PHST- 2008/06/13 09:00 [medline]
PHST- 2008/04/25 09:00 [entrez]
AID - 10.1002/lt.21443 [doi]
PST - ppublish
SO  - Liver Transpl. 2008 May;14(5):688-94. doi: 10.1002/lt.21443.