PMID- 18433738
OWN - NLM
STAT- MEDLINE
DCOM- 20080808
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1211
DP  - 2008 May 23
TI  - Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and 
      striatal gene expression in mice.
PG  - 1-5
LID - 10.1016/j.brainres.2008.03.016 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA), a widely used recreational drug with 
      psychoactive properties, induces both serotonin and dopamine release in the 
      brain. In rats and mice MDMA induces behavioural changes and has rewarding 
      effects but little is known about its cellular effects. We have previously shown 
      that the ERK pathway is important for the changes in gene expression observed in 
      mice striatum after treatment with this psychostimulant. In this study we 
      investigated the role of D1 receptors in MDMA-induced locomotor hyperactivity and 
      regulation of immediate-early genes (Fos, Fosb, Egr1 and Egr2) mRNA levels 
      requiring ERK activity in mice striatum. We used the selective D1 receptor 
      antagonist, SCH23390 at a dose (0.05 mg/kg) that did not influence locomotor 
      activity. This dose totally blocked MDMA-induced locomotor activity but only 
      partially the increase in transcription levels of Fos, Fosb, Egr1 and Egr2 (24%, 
      23%, 22% and 29% respectively). In conclusion, our results showed that D1 
      receptors play a key role in the acute MDMA-induced hyperlocomotion and that ERK 
      pathway is partially under D1 receptors control to induce Fos, FosB, Egr1 and 
      Egr2 transcription.
FAU - Benturquia, Nadia
AU  - Benturquia N
AD  - Laboratoire de Neuropsychopharmacologie des addictions, (INSERM U705, CNRS UMR 
      7157), Universite Paris Descartes, Faculte de pharmacie, Paris, France.
FAU - Courtin, Cindie
AU  - Courtin C
FAU - Noble, Florence
AU  - Noble F
FAU - Marie-Claire, Cynthia
AU  - Marie-Claire C
LA  - eng
PT  - Journal Article
DEP - 20080320
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Hallucinogens)
RN  - 0 (Receptors, Dopamine D1)
RN  - 63231-63-0 (RNA)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Benzazepines/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neostriatum/drug effects/*metabolism
MH  - RNA/biosynthesis/isolation & purification
MH  - Receptors, Dopamine D1/*drug effects
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/04/25 09:00
MHDA- 2008/08/09 09:00
CRDT- 2008/04/25 09:00
PHST- 2007/12/17 00:00 [received]
PHST- 2008/02/08 00:00 [revised]
PHST- 2008/03/07 00:00 [accepted]
PHST- 2008/04/25 09:00 [pubmed]
PHST- 2008/08/09 09:00 [medline]
PHST- 2008/04/25 09:00 [entrez]
AID - S0006-8993(08)00661-6 [pii]
AID - 10.1016/j.brainres.2008.03.016 [doi]
PST - ppublish
SO  - Brain Res. 2008 May 23;1211:1-5. doi: 10.1016/j.brainres.2008.03.016. Epub 2008 
      Mar 20.