PMID- 1843454
OWN - NLM
STAT- MEDLINE
DCOM- 19911101
LR  - 20220330
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 88
IP  - 4
DP  - 1991 Oct
TI  - Monocyte chemoattractant protein-1 in human atheromatous plaques.
PG  - 1121-7
AB  - Monocytes appear to be central to atherogenesis both as the progenitors of foam 
      cells and as a potential source of growth factors mediating intimal hyperplasia, 
      but the chemical messages which stimulate the influx of monocytes into human 
      atheroma remain unknown. Monocyte chemoattractant protein-1 (MCP-1) is a recently 
      described molecule with powerful monocyte chemotactic activity expressed by 
      monocytes, vascular endothelial cells, and smooth muscle cells in culture. To 
      begin to address the role of MCP-1 in vivo, we examined 10 normal arteries and 14 
      diseased human arteries for MCP-1 expression by in situ hybridization. MCP-1 mRNA 
      was detected in 16% of 10,768 cells counted in human carotid endarterectomy 
      specimens with highest expression seen in organizing thrombi (33%) and in 
      macrophage rich areas bordering the necrotic lipid core (24%) as compared to the 
      fibrous cap (8%) and the necrotic lipid core itself (5%). Based on 
      immunohistochemical staining of serial sections and on cell morphology, MCP-1 
      mRNA appeared to be expressed by vascular smooth muscle cells (VSMC), mesenchymal 
      appearing intimal cells (MICs), and macrophages. By contrast, few cells 
      expressing MCP-1 mRNA were found in normal arteries (less than 0.1%). These data 
      suggest a potential role for MCP-1 in mediating monocytic infiltration of the 
      artery wall.
FAU - Nelken, N A
AU  - Nelken NA
AD  - Cardiovascular Research Institute, University of California, San Francisco 94143.
FAU - Coughlin, S R
AU  - Coughlin SR
FAU - Gordon, D
AU  - Gordon D
FAU - Wilcox, J N
AU  - Wilcox JN
LA  - eng
GR  - F32 HL-08241/HL/NHLBI NIH HHS/United States
GR  - R01 HL-42119/HL/NHLBI NIH HHS/United States
GR  - R01 HL-43322/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Arteriosclerosis/*metabolism/pathology
MH  - Base Sequence
MH  - Cells, Cultured
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*analysis/*biosynthesis/genetics
MH  - Cytokines/pharmacology
MH  - Humans
MH  - Lipid Metabolism
MH  - Molecular Sequence Data
MH  - Muscle, Smooth, Vascular/chemistry
MH  - Nucleic Acid Hybridization
MH  - RNA, Messenger/analysis
PMC - PMC295565
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
PMCR- 1991/10/01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
PHST- 1991/10/01 00:00 [pmc-release]
AID - 10.1172/JCI115411 [doi]
PST - ppublish
SO  - J Clin Invest. 1991 Oct;88(4):1121-7. doi: 10.1172/JCI115411.