PMID- 18435478
OWN - NLM
STAT- MEDLINE
DCOM- 20080624
LR  - 20080505
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 43
IP  - 6
DP  - 2008 Jun
TI  - Acute respiratory symptoms and general illness during the first year of life: a 
      population-based birth cohort study.
PG  - 584-93
LID - 10.1002/ppul.20828 [doi]
AB  - Respiratory symptoms are common in infancy. Most illnesses occurring among 
      children are dealt with by parents and do not require medical attention. 
      Nevertheless, few studies have prospectively and on a community-basis assessed 
      the amount of respiratory symptoms and general illness in normal infants. In this 
      population-based birth cohort study, 228 healthy infants from Copenhagen, Denmark 
      were followed from birth to 1 year of age during 2004-2006. Symptoms were 
      registered using daily diaries and monthly home visits. Interviews were performed 
      at inclusion and every second month. Risk factor analysis was carried out by 
      multiple logistic regression analysis. On average, children had general symptoms 
      for 3.5 months during their first year of life, nasal discharge being most 
      frequent followed by cough. Frequency of all symptoms increased steeply after 6 
      months of age. Each child had on average 6.3 episodes (median: 5.1, 
      inter-quartile range (IQR): 3.3-7.8) of acute respiratory tract illness (ARTI) 
      (nasal discharge and > or = 1 of the following symptoms: cough, fever, wheezing, 
      tachypnea, malaise, or lost appetite) and 5.6 episodes (median: 4.3, IQR: 
      2.1-7.3) of simple rhinitis per 365 days at risk. Determinants for respiratory 
      symptoms were increasing age, winter season, household size, size of residence, 
      day-care attendance, and having siblings aged 1-3 years attending a day nursery. 
      In conclusion, the present study provides detailed data on the occurrence of 
      disease symptoms during the first year of life in a general population cohort and 
      emphasizes the impact of increasing age, seasonality, and living conditions on 
      the occurrence of ARTI.
FAU - von Linstow, Marie-Louise
AU  - von Linstow ML
AD  - Department of Pediatrics, Hvidovre Hospital, University of Copenhagen, Denmark. 
      linstow@dadlnet.dk
FAU - Holst, Klaus Kahler
AU  - Holst KK
FAU - Larsen, Karina
AU  - Larsen K
FAU - Koch, Anders
AU  - Koch A
FAU - Andersen, Per Kragh
AU  - Andersen PK
FAU - Hogh, Birthe
AU  - Hogh B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Interviews as Topic
MH  - Logistic Models
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - Respiratory Tract Infections/*epidemiology
MH  - Risk Factors
EDAT- 2008/04/26 09:00
MHDA- 2008/06/25 09:00
CRDT- 2008/04/26 09:00
PHST- 2008/04/26 09:00 [pubmed]
PHST- 2008/06/25 09:00 [medline]
PHST- 2008/04/26 09:00 [entrez]
AID - 10.1002/ppul.20828 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2008 Jun;43(6):584-93. doi: 10.1002/ppul.20828.