PMID- 18435579
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20151119
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Linking)
VI  - 23
IP  - 6
DP  - 2008 Jun
TI  - Caloric restriction decreases cortical bone mass but spares trabecular bone in 
      the mouse skeleton: implications for the regulation of bone mass by body weight.
PG  - 870-8
LID - 10.1359/jbmr.080213 [doi]
AB  - INTRODUCTION: Body weight is positively correlated with bone mass and density, 
      and both muscle mass and body fat are thought to play a role in regulating bone 
      metabolism. We examined bone metabolism in calorically restricted mice to 
      determine how alterations in soft tissue mass affect bone mass, density, and 
      strength. MATERIALS AND METHODS: Caloric restriction (CR) was initiated in male 
      mice at 14 wk of age at 10% restriction, increased to 25% restriction at 15 wk, 
      and then increased to 40% restriction at 16 wk, where it was maintained until 24 
      wk of age when the study was terminated. Control mice were fed ad libitum (AL). 
      Body composition, BMD, and BMC were measured by DXA, BMD and BMC in the femoral 
      metaphysis were measured by pQCT, femora were tested in three-point bending, 
      serum leptin and IGF-1 were measured using immunoassay, and osteoblast and 
      osteoclast numbers were determined using histomorphometry. RESULTS: Body weight, 
      lean mass, fat mass, percent body fat, serum leptin, and serum IGF-1 were all 
      significantly lower in CR mice than AL mice. Whole body BMC and BMD did not 
      differ significantly between the two groups. Femur BMC, BMD, cortical thickness, 
      and fracture strength decreased significantly in CR mice, but trabecular bone 
      volume fraction in the femur did not change with food restriction. Vertebral 
      cortical thickness also decreased with caloric restriction, whereas spine BMC, 
      BMD, and trabecular bone volume fraction were significantly increased with 
      caloric restriction. CONCLUSIONS: Caloric restriction and its related weight 
      reduction are associated with marked decreases in lean mass, fat mass, serum 
      leptin and IGF-1, and cortical bone mass. Consistent with the opposite effects of 
      leptin on cortical and cancellous bone, trabecular bone mass is spared during 
      food restriction.
FAU - Hamrick, Mark W
AU  - Hamrick MW
AD  - Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, 
      Georgia 30912, USA. mhamrick@mail.mcg.edu
FAU - Ding, Ke-Hong
AU  - Ding KH
FAU - Ponnala, Sumant
AU  - Ponnala S
FAU - Ferrari, Serge L
AU  - Ferrari SL
FAU - Isales, Carlos M
AU  - Isales CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - *Body Weight
MH  - Bone Density/*physiology
MH  - Bone and Bones/*physiology
MH  - *Caloric Restriction
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Leptin/blood
MH  - Male
MH  - Mice
MH  - Organ Size
EDAT- 2008/04/26 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/04/26 09:00
PHST- 2008/04/26 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/04/26 09:00 [entrez]
AID - 10.1359/jbmr.080213 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2008 Jun;23(6):870-8. doi: 10.1359/jbmr.080213.