PMID- 18438015
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20161124
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 26
IP  - 1
DP  - 2008 Jan
TI  - [Analysis of hexabromocyclododecane diastereoisomers in foods of animal origin 
      using ultra performance liquid chromatography-mass spectgrometry and isotope 
      dilution].
PG  - 1-5
AB  - A method for the detection of the alpha, beta and gamma-diastereoisomers of 
      hexabromocyclododecane (HBCDs) in foods of animal origin, such as fish, chick, 
      milk, butter etc., was developed using ultra performance liquid 
      chromatography-electrospray ionization mass spectrometry (UPLC-ESI-MS) and 
      isotope dilution. The HBCDs with the spiked isotopic 13C-HBCDs, the internal 
      standards, were extracted using Soxhiet extraction, and further purified using 
      acidic silica treatment and solid phase extraction. The separation of HBCDs was 
      performed on Waters ACQUITY UPLC system with the column of BEH C8 and the 
      gradient elution solvent of methanol-acetonitrile and water at a flow rate of 0.2 
      mL/min. The HBCDs were identified on the basis of the retention times and 
      precursor ions, and quantitatively determined under the selected ion recording 
      mode, m/z 640.7 for the [M-H]-ion. The limits of detection (LODs) of HBCDs ranged 
      from 0.1 to 0.4 ng/g; and the limits of quantification (LOQs) ranged from 0.4 to 
      1.2 ng/g. The average recoveries ranged from 92.9% to 99.3% for the spiked levels 
      of 0.6, 2.0 and 6.0 ng/g. with the relative standard deviations (RSDs) between 
      3.1% and 8.0%.
FAU - Shi, Zhixiong
AU  - Shi Z
AD  - National Institute for Nutrition and Food Safety, Chinese Center for Disease 
      Control and Prevention, Beijing, China. szx0127@ccmu.edu.cn
FAU - Feng, Jinfang
AU  - Feng J
FAU - Li, Jingguang
AU  - Li J
FAU - Zhao, Yunfeng
AU  - Zhao Y
FAU - Wu, Yongning
AU  - Wu Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Isotopes)
RN  - 5I9835JO3M (hexabromocyclododecane)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Food Analysis/*methods
MH  - Hydrocarbons, Brominated/*analysis/*chemistry
MH  - Isotopes
MH  - Limit of Detection
MH  - Linear Models
MH  - Mass Spectrometry/*methods
MH  - Stereoisomerism
MH  - Time Factors
EDAT- 2008/04/29 09:00
MHDA- 2010/06/18 06:00
CRDT- 2008/04/29 09:00
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2008 Jan;26(1):1-5.