PMID- 18439471
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20080428
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 138
IP  - 5
DP  - 2008 May
TI  - Chronic otitis media and immunoglobulin E-mediated hypersensitivity in adults: is 
      it a contributor of cholesteatoma?
PG  - 637-40
LID - 10.1016/j.otohns.2007.12.037 [doi]
AB  - OBJECTIVES: The aim of this study was to determine the relationship between 
      chronic otitis media (COM) and immunoglobulin E (IgE)-mediated hypersensitivity 
      in adults. STUDY DESIGN: A prospective comparative study. SUBJECTS AND METHODS: 
      One hundred seventeen patients with COM from July 2005 to April 2007 were 
      enrolled. All subjects had a questionnaire on allergic rhinitis symptoms and 
      performed allergy tests that included a total IgE and the multiple 
      radioallergosorbent chemiluminescence assay to check the presence of IgE-mediated 
      hypersensitivity. RESULTS: The prevalence of IgE-mediated hypersensitivity and 
      allergic rhinitis were 22.2% and 7.7% in patients with COM, respectively. The 
      mean total IgE was 157.2 ranging from 3 to 1833. The prevalence of IgE-mediated 
      hypersensitivity was similar with regard to the recurrence or bilaterality. 
      However, patients with cholesteatoma had a higher prevalence of IgE-mediated 
      hypersensitivity than patients without that condition. CONCLUSION: The prevalence 
      of IgE-mediated hypersensitivity and allergic rhinitis in adults with COM 
      appeared to be higher than in the general population. Allergy might contribute to 
      COM especially in cases with a cholesteatoma.
FAU - Hong, Sang Duk
AU  - Hong SD
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Gangnam-Gu, Seoul, Korea.
FAU - Cho, Yang-Sun
AU  - Cho YS
FAU - Hong, Sung Hwa
AU  - Hong SH
FAU - Chung, Won-Ho
AU  - Chung WH
FAU - Chung, Kyu-Whan
AU  - Chung KW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cholesteatoma, Middle Ear/*etiology
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Otitis Media/*complications
MH  - Prospective Studies
EDAT- 2008/04/29 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/04/29 09:00
PHST- 2007/08/28 00:00 [received]
PHST- 2007/11/25 00:00 [revised]
PHST- 2007/12/26 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
AID - S0194-5998(08)00002-8 [pii]
AID - 10.1016/j.otohns.2007.12.037 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2008 May;138(5):637-40. doi: 
      10.1016/j.otohns.2007.12.037.