PMID- 18439563
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20211020
IS  - 0002-9394 (Print)
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 146
IP  - 1
DP  - 2008 Jul
TI  - Ultrastructural correlation of spectral-domain optical coherence tomographic 
      findings in vitreomacular traction syndrome.
PG  - 121-7
LID - 10.1016/j.ajo.2008.03.001 [doi]
AB  - PURPOSE: To examine the ultrastructural correlates of spectral-domain optical 
      coherence tomography (SD-OCT) findings in patients with vitreomacular traction 
      (VMT). DESIGN: Observational case series. METHODS: Retrospective analysis of six 
      eyes of consecutive patients who underwent vitrectomy surgery for VMT was 
      performed in this single-center, noncomparative study. One patient had a 
      concurrent macular hole. Preoperative assessment included SD-OCT examination with 
      3-dimensional image reconstruction. During surgery the vitreous cone was 
      dissected from the vitreous body using scissors, then removed from the surface of 
      the retina with a combination of sharp dissection and peeling, and subsequently 
      submitted for histologic and transmission electron microscopic processing. 
      RESULTS: SD-OCT showed prominent vitreal-foveal adhesion in all six eyes. Each 
      eye had an epiretinal membrane (ERM) under the detached perifoveal posterior 
      vitreous detachment. In all eyes this ERM appeared to course up the cone of 
      attached vitreous and along the back surface of the posterior vitreous face. 
      Ultrastructural analysis showed fibrocellular proliferations in the vitreous 
      specimens in all six cases, which included retinal pigment epithelium (RPE) cells 
      (five eyes), fibrocytes (four eyes), and macrophages (three eyes). CONCLUSIONS: 
      The adhesion between the vitreous and fovea in vitreomacular traction syndrome is 
      accompanied by fibrocellular proliferation along the exposed surfaces of the 
      inner retina and the posterior surface of the vitreous. This fibrocellular 
      proliferation may augment the adhesion between the vitreous and fovea, and may 
      account for the prominent OCT signal seen along the posterior surface of the 
      vitreous in these cases.
FAU - Chang, Louis K
AU  - Chang LK
AD  - Vitreous-Retina-Macula Consultants of New York, and the LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY 10022, 
      USA.
FAU - Fine, Howard F
AU  - Fine HF
FAU - Spaide, Richard F
AU  - Spaide RF
FAU - Koizumi, Hideki
AU  - Koizumi H
FAU - Grossniklaus, Hans E
AU  - Grossniklaus HE
LA  - eng
GR  - P30 EY006360-25/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080425
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Epiretinal Membrane/*pathology/surgery
MH  - Eye Diseases/*pathology/surgery
MH  - Female
MH  - Fibroblasts/ultrastructure
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Macrophages/ultrastructure
MH  - Macula Lutea/*ultrastructure
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Pigment Epithelium of Eye/ultrastructure
MH  - Retrospective Studies
MH  - Syndrome
MH  - Tissue Adhesions/pathology
MH  - Tomography, Optical Coherence
MH  - Vitrectomy
MH  - Vitreous Body/*ultrastructure
PMC - PMC2987706
MID - NIHMS239307
EDAT- 2008/04/29 09:00
MHDA- 2008/07/23 09:00
PMCR- 2010/11/18
CRDT- 2008/04/29 09:00
PHST- 2008/01/01 00:00 [received]
PHST- 2008/02/20 00:00 [revised]
PHST- 2008/03/02 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
PHST- 2010/11/18 00:00 [pmc-release]
AID - S0002-9394(08)00166-9 [pii]
AID - 10.1016/j.ajo.2008.03.001 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2008 Jul;146(1):121-7. doi: 10.1016/j.ajo.2008.03.001. Epub 2008 
      Apr 25.