PMID- 18439624
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20211020
IS  - 0022-510X (Print)
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 270
IP  - 1-2
DP  - 2008 Jul 15
TI  - Standing balance and trunk position sense in impaired glucose tolerance 
      (IGT)-related peripheral neuropathy.
PG  - 165-71
LID - 10.1016/j.jns.2008.03.002 [doi]
AB  - Type 2 diabetes mellitus (T2DM) and pre-diabetes or impaired glucose tolerance 
      (IGT) affect a large segment of the population. Peripheral neuropathy (PN) is a 
      common complication of T2DM, leading to sensory and motor deficits. While 
      T2DM-related PN often results in balance- and mobility-related dysfunction which 
      manifests as gait instability and falls, little is known about balance 
      capabilities in patients who have evidence of PN related to IGT (IGT-PN). We 
      evaluated patients with IGT-PN on commonly-used clinical balance and mobility 
      tests as well as a new test of trunk position sense and balance impairment, trunk 
      repositioning errors (TREs). Eight participants aged 50-72 years with IGT-PN, and 
      eight age- and gender-matched controls underwent balance, mobility and trunk 
      repositioning accuracy tests at a university neurology clinic and mobility 
      research laboratory. Compared to controls, IGT-PN participants had as much as 
      twice the magnitude of TREs and stood approximately half as long on the single 
      leg balance test. People with IGT-PN exhibit deficits in standing balance and 
      trunk position sense. Furthermore, there was a significant association between 
      performance on commonly-used clinical balance and mobility tests, and 
      electrophysiological and clinical measures of neuropathy in IGT-PN participants. 
      Because IGT-related neuropathy represents the earliest stage of diabetic 
      neuropathy, deficits in IGT-PN participants highlight the importance of early 
      screening in the dysglycemic process for neuropathy and associated balance 
      deficits.
FAU - Goldberg, Allon
AU  - Goldberg A
AD  - Department of Health Care Sciences, Wayne State University, Detroit MI, USA. 
      agoldberg@wayne.edu
FAU - Russell, James William
AU  - Russell JW
FAU - Alexander, Neil Burton
AU  - Alexander NB
LA  - eng
GR  - T32 AG000114/AG/NIA NIH HHS/United States
GR  - M01-RR00042/RR/NCRR NIH HHS/United States
GR  - K02 NS042056/NS/NINDS NIH HHS/United States
GR  - P30 AG024824/AG/NIA NIH HHS/United States
GR  - M01 RR000042-47/RR/NCRR NIH HHS/United States
GR  - AG024824/AG/NIA NIH HHS/United States
GR  - K24 AG019675/AG/NIA NIH HHS/United States
GR  - AG109675/AG/NIA NIH HHS/United States
GR  - M01 RR000042/RR/NCRR NIH HHS/United States
GR  - P30 AG024824-04/AG/NIA NIH HHS/United States
GR  - 5P60DK-20572/DK/NIDDK NIH HHS/United States
GR  - NS42056/NS/NINDS NIH HHS/United States
GR  - T32 AG000114-24/AG/NIA NIH HHS/United States
GR  - P30 DK092926/DK/NIDDK NIH HHS/United States
GR  - P60 DK020572-29/DK/NIDDK NIH HHS/United States
GR  - AG100114/AG/NIA NIH HHS/United States
GR  - K02 NS042056-05/NS/NINDS NIH HHS/United States
GR  - P60 DK020572/DK/NIDDK NIH HHS/United States
GR  - K24 AG019675-05/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080425
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Glucose Intolerance/epidemiology/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Movement/physiology
MH  - Peripheral Nervous System Diseases/*complications/epidemiology
MH  - Postural Balance/*physiology
MH  - *Posture
MH  - Time Factors
PMC - PMC2705326
MID - NIHMS56605
EDAT- 2008/04/29 09:00
MHDA- 2008/09/25 09:00
PMCR- 2009/07/15
CRDT- 2008/04/29 09:00
PHST- 2007/08/17 00:00 [received]
PHST- 2008/01/22 00:00 [revised]
PHST- 2008/03/07 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
PHST- 2009/07/15 00:00 [pmc-release]
AID - S0022-510X(08)00135-4 [pii]
AID - 10.1016/j.jns.2008.03.002 [doi]
PST - ppublish
SO  - J Neurol Sci. 2008 Jul 15;270(1-2):165-71. doi: 10.1016/j.jns.2008.03.002. Epub 
      2008 Apr 25.